4.5 Article

Protective effects of mitophagy enhancers against amyloid beta-induced mitochondrial and synaptic toxicities in Alzheimer disease

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

Protective effects of a small molecule inhibitor ligand against hyperphosphorylated tau-induced mitochondrial and synaptic toxicities in Alzheimer disease

Jangampalli Adi Pradeepkiran et al.

Summary: The study aimed to understand the protective effects of small molecule ligands for phosphorylated tau in AD progression. Small molecule ligands binding to phosphorylated tau can reduce tau hyperphosphorylation levels in AD and promote mitochondrial biogenesis and synaptic activities while decreasing mitochondrial fission.

HUMAN MOLECULAR GENETICS (2022)

Review Cell Biology

Synaptic basis of Alzheimer's disease: Focus on synaptic amyloid beta, P-tau and mitochondria

Albin John et al.

Summary: Alzheimer's disease is a progressive disease associated with synaptic dysfunction, with researchers striving to find more information on disease progression and pathogenesis. Synaptic pathology and mitochondrial oxidative damage are early events in the progression of AD, with synaptic loss and damage being key correlates of cognitive deficits in patients. As the disease advances, significant changes occur at the synapse, shedding light on the disease progression and serving as potential markers and therapeutic targets.

AGEING RESEARCH REVIEWS (2021)

Review Neurosciences

Defective Autophagy and Mitophagy in Aging and Alzheimer's Disease

Michael Tran et al.

Summary: Aging is a time-dependent process characterized by declining physiological function due to metabolic and molecular changes. Factors such as epigenetic changes, telomere length, oxidative damage, and mitochondrial dysfunction play major roles in assessing biological age. Dysfunctions in autophagy and mitophagy are implicated in the pathogenesis of age-related diseases like Alzheimer's disease.

FRONTIERS IN NEUROSCIENCE (2021)

Article Biochemistry & Molecular Biology

Protective effects of antidepressant citalopram against abnormal APP processing and amyloid beta-induced mitochondrial dynamics, biogenesis, mitophagy and synaptic toxicities in Alzheimer's disease

Arubala P. Reddy et al.

Summary: The study found that citalopram has a protective effect against mutant APP, Aβ, and mitochondrial toxicities, suggesting a potential neuroprotective role in patients with depression, anxiety, and AD.

HUMAN MOLECULAR GENETICS (2021)

Article Cell Biology

Bioenergetic and inflammatory systemic phenotypes in Alzheimer's disease APOE ε4-carriers

Heather M. Wilkins et al.

Summary: The study revealed that the APOE ε4 genotype affects platelet and lymphocyte metabolism in Alzheimer's disease patients, showing lower platelet mitochondrial activity and higher lymphocyte apoptosis markers in APOE ε4 carriers. Proteins related to mitophagy and energy sensing were elevated in APOE ε4 lymphocytes, possibly representing compensatory changes. RNA sequencing also indicated activation of inflammatory pathways and modulation of bioenergetic signaling in APOE ε4 carriers.

AGING CELL (2021)

Review Biochemistry & Molecular Biology

Mitochondrial dynamics in health and disease

Nethmi M. B. Yapa et al.

Summary: Mitochondria in animals form interconnected tubular networks through fission and fusion mechanisms, which are crucial for maintaining cellular and organismal health. Imbalance in mitochondrial dynamics can lead to diseases, including neurodegenerative disorders.

FEBS LETTERS (2021)

Article Biochemistry & Molecular Biology

Selective serotonin reuptake inhibitor citalopram ameliorates cognitive decline and protects against amyloid beta-induced mitochondrial dynamics, biogenesis, autophagy, mitophagy and synaptic toxicities in a mouse model of Alzheimer's disease

Arubala P. Reddy et al.

Summary: The study investigates the protective role of citalopram against cognitive decline, impaired mitochondrial dynamics, and synaptic dysfunction in an Alzheimer's disease mouse model. Citalopram treatment improved cognitive behavior, reduced Aβ levels, and decreased mitochondrial and synaptic toxicities in the treated mice compared to the untreated mice. The findings suggest that citalopram may have a strong protective effect against injuries induced by mutant APP and Aβ in depression, anxiety, and AD patients.

HUMAN MOLECULAR GENETICS (2021)

Article Biochemistry & Molecular Biology

Defective mitophagy and synaptic degeneration in Alzheimer's disease: Focus on aging, mitochondria and synapse

Hallie Morton et al.

Summary: Alzheimer's disease is a progressive neurodegenerative disease characterized by multiple cellular changes, mitochondrial dysfunction, and brain damage, ultimately leading to cognitive impairment.

FREE RADICAL BIOLOGY AND MEDICINE (2021)

Article Neurosciences

Exosomes as a potential messenger unit during heterochronic parabiosis for amelioration of Huntington's disease

Mijung Lee et al.

Summary: Huntington's disease (HD) shows its pathology before clinical manifestation, with few therapies available. Heterochronic parabiosis has been shown to modulate neurodegenerative diseases, and this study demonstrated its potential to improve HD pathology by sharing positive factors through exosomes in young blood serum.

NEUROBIOLOGY OF DISEASE (2021)

Review Biochemistry & Molecular Biology

Impact of the Natural Compound Urolithin A on Health, Disease, and Aging

Davide D'Amico et al.

Summary: Urolithin A is a natural compound derived from gut bacteria, with benefits such as enhancing cellular health and reducing inflammation. Preclinical studies have shown that UA plays a crucial role in protecting muscles, brain, joints, and other organs from aging and age-related conditions.

TRENDS IN MOLECULAR MEDICINE (2021)

Review Neurosciences

Age-Related Chronic Diseases and Alzheimer's Disease in Texas: A Hispanic Focused Study

Shyam Sheladia et al.

Summary: The increase in age-related chronic diseases in the United States directly contributes to the development of dementia, with both unmodifiable and modifiable risk factors playing a role. Hispanic Americans in the U.S. are particularly vulnerable to dementia and also face challenges in accessing healthcare services.

JOURNAL OF ALZHEIMERS DISEASE REPORTS (2021)

Review Biochemistry & Molecular Biology

Mitochondrial division, fusion and degradation

Daisuke Murata et al.

JOURNAL OF BIOCHEMISTRY (2020)

Review Neurosciences

Mitochondria dysfunction in the pathogenesis of Alzheimer's disease: recent advances

Wenzhang Wang et al.

MOLECULAR NEURODEGENERATION (2020)

Review Biochemistry & Molecular Biology

Dietary Mitophagy Enhancer: A Strategy for Healthy Brain Aging?

Nimmy Varghese et al.

ANTIOXIDANTS (2020)

Review Biochemistry & Molecular Biology

Mitophagy and the Brain

Natalie S. Swerdlow et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Biochemistry & Molecular Biology

Nrf2/ARE Pathway as a Therapeutic Target for the Treatment of Parkinson Diseases

Artem P. Gureev et al.

NEUROCHEMICAL RESEARCH (2019)

Article Biochemistry & Molecular Biology

Parkin-mediated mitophagy in mutant hAPP neurons and Alzheimer's disease patient brains

Xuan Ye et al.

HUMAN MOLECULAR GENETICS (2015)

Review Neurosciences

Mitochondrial dynamic abnormalities in amyotrophic lateral sclerosis

Zhen Jiang et al.

TRANSLATIONAL NEURODEGENERATION (2015)

Review Biochemistry & Molecular Biology

The Alzheimer's disease mitochondrial cascade hypothesis: Progress and perspectives

Russell H. Swerdlow et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2014)

Article Pharmacology & Pharmacy

Mitochondrial Biogenesis in Health and Disease. Molecular and Therapeutic Approaches

Fabian Sanchis-Gomar et al.

CURRENT PHARMACEUTICAL DESIGN (2014)

Editorial Material Pharmacology & Pharmacy

Mitochondrial Biogenesis: Pharmacological Approaches

Teresa Valero

CURRENT PHARMACEUTICAL DESIGN (2014)

Review Neurosciences

Abnormal Mitochondrial Dynamics in the Pathogenesis of Alzheimer's Disease

Xiongwei Zhu et al.

JOURNAL OF ALZHEIMERS DISEASE (2013)

Review Biochemistry & Molecular Biology

Abnormal mitochondrial dynamics and synaptic degeneration as early events in Alzheimer's disease: Implications to mitochondria-targeted antioxidant therapeutics

P. Hemachandra Reddy et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2012)

Article Biochemistry & Molecular Biology

Impaired mitochondrial biogenesis contributes to mitochondrial dysfunction in Alzheimer's disease

Baiyang Sheng et al.

JOURNAL OF NEUROCHEMISTRY (2012)

Article Medicine, General & Internal

Clinical and Biomarker Changes in Dominantly Inherited Alzheimer's Disease

Randall J. Bateman et al.

NEW ENGLAND JOURNAL OF MEDICINE (2012)

Review Biochemistry & Molecular Biology

Aging and amyloid beta-induced oxidative DNA damage and mitochondrial dysfunction in Alzheimer's disease: Implications for early intervention and therapeutics

Peizhong Mao et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2011)

Review Neurosciences

Dynamin-related protein 1 and mitochondrial fragmentation in neurodegenerative diseases

P. Hemachandra Reddy et al.

BRAIN RESEARCH REVIEWS (2011)

Article Biochemistry & Molecular Biology

Parkin mediates beclin-dependent autophagic clearance of defective mitochondria and ubiquitinated Aβ in AD models

Preeti J. Khandelwal et al.

HUMAN MOLECULAR GENETICS (2011)

Review Neurosciences

Amyloid beta, mitochondrial structural and functional dynamics in Alzheimer's disease

P. Hemachandra Reddy

EXPERIMENTAL NEUROLOGY (2009)

Article Biochemistry & Molecular Biology

The role of abnormal mitochondrial dynamics in the pathogenesis of Alzheimer's disease

Xinglong Wang et al.

JOURNAL OF NEUROCHEMISTRY (2009)

Article Neurosciences

Impaired Balance of Mitochondrial Fission and Fusion in Alzheimer's Disease

Xinglong Wang et al.

JOURNAL OF NEUROSCIENCE (2009)

Article Multidisciplinary Sciences

Amyloid-β overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins

Xinglong Wang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Review Biochemistry & Molecular Biology

Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease

P. Hemachandra Reddy et al.

TRENDS IN MOLECULAR MEDICINE (2008)

Review Biochemistry & Molecular Biology

Emerging functions of mammalian mitochondrial fusion and fission

HC Chen et al.

HUMAN MOLECULAR GENETICS (2005)

Review Multidisciplinary Sciences

Pathways towards and away from Alzheimer's disease

MP Mattson

NATURE (2004)

Article Neurosciences

Mitochondrial abnormalities in Alzheimer's disease

K Hirai et al.

JOURNAL OF NEUROSCIENCE (2001)

Review Physiology

Alzheimer's disease: Genes, proteins, and therapy

DJ Selkoe

PHYSIOLOGICAL REVIEWS (2001)