期刊
HUMAN IMMUNOLOGY
卷 82, 期 7, 页码 505-522出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.humimm.2021.04.007
关键词
Human leukocyte antigen; Next-generation sequencing; International HLA and Immunogenetics; Workshop; Allele frequency; Haplotype frequency
类别
资金
- Stanford Blood center
The unrelated population HLA diversity project aimed to characterize HLA alleles at maximum allelic-resolution in worldwide populations. The study found significant differences in HLA diversity across populations, particularly with lower diversity observed in European-descent populations at 2- and 4-field allelic resolution. This reference data of HLA profiles from various populations is valuable for anthropological studies, transplantation, and disease association studies.
The primary goal of the unrelated population HLA diversity (UPHD) component of the 17th International HLA and Immunogenetics Workshop was to characterize HLA alleles at maximum allelic-resolution in worldwide populations and re-evaluate patterns of HLA diversity across populations. The UPHD project included HLA genotype and sequence data, generated by various next-generation sequencing methods, from 4,240 individuals collated from 12 different countries. Population data included well-defined large datasets from the USA and smaller samples from Europe, Australia, and Western Asia. Allele and haplotype frequencies varied across populations from distant geographical regions. HLA genetic diversity estimated at 2- and 4-field allelic resolution revealed that diversity at the majority of loci, particularly for European-descent populations, was lower at the 2-field resolution. Several common alleles with identical protein sequences differing only by intronic substitutions were found in distinct haplotypes, revealing a more detailed characterization of linkage between variants within the HLA region. The examination of coding and non-coding nucleotide variation revealed many examples in which almost complete biunivocal relations between common alleles at different loci were observed resulting in higher linkage disequilibrium. Our reference data of HLA profiles characterized at maximum resolution from many populations is useful for anthropological studies, unrelated donor searches, transplantation, and disease association studies. (c) 2021 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据