期刊
HUMAN BRAIN MAPPING
卷 42, 期 12, 页码 4022-4034出版社
WILEY
DOI: 10.1002/hbm.25536
关键词
activation; diffusion tensor imaging; fMRI; frontal; schizophrenia; white matter
资金
- CAMS Innovation Fund for Medical Sciences(CIFMS) [2019-I2M-5-039]
- National Key R&D Program of China [2018YFA0701400]
- National Natural Science Foundation of China [61933003, 81771822, 81771925, 81861128001, U2033217, 31371134, 31070905]
- Project of Science and Technology Department of Sichuan Province [2019YJ0179]
- National Social Science Foundation of China [11AZD119]
- Center of Biomedical Research Excellence (COBRE) [P20GM103472, 5P20RR021938]
This study reveals a reversed pattern of structure and function in frontotemporal tracts in schizophrenia, with negative associations between structural deficits and functional disturbances in patients, exacerbated by long illness duration and severe negative symptoms. Additionally, white matter activations are significantly related to cognition and emotion.
White matter (WM) microstructure deficit may be an underlying factor in the brain dysconnectivity hypothesis of schizophrenia using diffusion tensor imaging (DTI). However, WM dysfunction is unclear in schizophrenia. This study aimed to investigate the association between structural deficits and functional disturbances in major WM tracts in schizophrenia. Using functional magnetic resonance imaging (fMRI) and DTI, we developed the skeleton-based WM functional analysis, which could achieve voxel-wise function-structure coupling by projecting the fMRI signals onto a skeleton in WM. We measured the fractional anisotropy (FA) and WM low-frequency oscillation (LFO) and their couplings in 93 schizophrenia patients and 122 healthy controls (HCs). An independent open database (62 schizophrenia patients and 71 HCs) was used to test the reproducibility. Finally, associations between WM LFO and five behaviour assessment categories (cognition, emotion, motor, personality and sensory) were examined. This study revealed a reversed pattern of structure and function in frontotemporal tracts, as follows. (a) WM hyper-LFO was associated with reduced FA in schizophrenia. (b) The function-structure association was positive in HCs but negative in schizophrenia patients. Furthermore, function-structure dissociation was exacerbated by long illness duration and severe negative symptoms. (c) WM activations were significantly related to cognition and emotion. This study indicated function-structure dys-coupling, with higher LFO and reduced structural integration in frontotemporal WM, which may reflect a potential mechanism in WM neuropathologic processing of schizophrenia.
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