期刊
HUMAN BRAIN MAPPING
卷 42, 期 13, 页码 4298-4313出版社
WILEY
DOI: 10.1002/hbm.25547
关键词
amplitude of low‐ frequency fluctuation; cardiorespiratory modulation; fast fMRI; global signal; physiological brain pulsations; resting state
资金
- Academy of Finland/Aivosaatio TERVA 1-2 [275342, 314497, 335720]
- Instrumentariumin Tiedesaatio
- Jane ja Aatos Erkon Saatio
- Maire Taposen Saatio
- Medical Research Center Oulu
- PohjoisSuomen Terveydenhuollon Tukisaatio
- Suomen Aivosaatio
- Suomen Laaketieteen Saatio
- University of Oulu Scholarship Foundation
- VTR grants from Oulu University Hospital
- Academy of Finland (AKA) [314497, 335720, 314497] Funding Source: Academy of Finland (AKA)
Physiological pulsations, previously considered noise, have been shown to potentially serve as biomarkers for brain pathology. Respiratory pulsations dominate most brain structures, while VLF, cardiac, and CREM pulsations have varying effects in different brain regions.
Physiological pulsations have been shown to affect the global blood oxygen level dependent (BOLD) signal in human brain. While these pulsations have previously been regarded as noise, recent studies show their potential as biomarkers of brain pathology. We used the extended 5 Hz spectral range of magnetic resonance encephalography (MREG) data to investigate spatial and frequency distributions of physiological BOLD signal sources. Amplitude spectra of the global image signals revealed cardiorespiratory envelope modulation (CREM) peaks, in addition to the previously known very low frequency (VLF) and cardiorespiratory pulsations. We then proceeded to extend the amplitude of low frequency fluctuations (ALFF) method to each of these pulsations. The respiratory pulsations were spatially dominating over most brain structures. The VLF pulsations overcame the respiratory pulsations in frontal and parietal gray matter, whereas cardiac and CREM pulsations had this effect in central cerebrospinal fluid (CSF) spaces and major blood vessels. A quasi-periodic pattern (QPP) analysis showed that the CREM pulsations propagated as waves, with a spatiotemporal pattern differing from that of respiratory pulsations, indicating them to be distinct intracranial physiological phenomenon. In conclusion, the respiration has a dominant effect on the global BOLD signal and directly modulates cardiovascular brain pulsations.
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