期刊
HUMAN BRAIN MAPPING
卷 42, 期 16, 页码 5309-5321出版社
WILEY
DOI: 10.1002/hbm.25619
关键词
brain stimulation; error rate; noninvasive; pain; picture naming; speech mapping; TMS; tolerability; virtual lesion
资金
- Deutsche Forschungsgemeinschaft [INST 1850/50-1]
- Universitat zu Koln [Gerok 8/2016]
Systematically testing the influence of different stimulation frequencies on language mapping, this study found that 30 Hz rTMS induced significantly more errors compared to 50 Hz, while error rates were comparable with 10 Hz. The error rate was higher in Session 1 compared to Session 2, and reliability between sessions was poor for 10 and 30 Hz, but moderate for 50 Hz.
Repetitive TMS (rTMS) with a frequency of 5-10 Hz is widely used for language mapping. However, it may be accompanied by discomfort and is limited in the number and reliability of evoked language errors. We, here, systematically tested the influence of different stimulation frequencies (i.e., 10, 30, and 50 Hz) on tolerability, number, reliability, and cortical distribution of language errors aiming at improved language mapping. 15 right-handed, healthy subjects (m = 8, median age: 29 yrs) were investigated in two sessions, separated by 2-5 days. In each session, 10, 30, and 50 Hz rTMS were applied over the left hemisphere in a randomized order during a picture naming task. Overall, 30 Hz rTMS evoked significantly more errors (20 +/- 12%) compared to 50 Hz (12 +/- 8%; p <.01), whereas error rates were comparable between 30/50 and 10 Hz (18 +/- 11%). Across all conditions, a significantly higher error rate was found in Session 1 (19 +/- 13%) compared to Session 2 (13 +/- 7%, p <.05). The error rate was poorly reliable between sessions for 10 (intraclass correlation coefficient, ICC = .315) and 30 Hz (ICC = .427), whereas 50 Hz showed a moderate reliability (ICC = .597). Spatial reliability of language errors was low to moderate with a tendency toward increased reliability for higher frequencies, for example, within frontal regions. Compared to 10 Hz, both, 30 and 50 Hz were rated as less painful. Taken together, our data favor the use of rTMS-protocols employing higher frequencies for evoking language errors reliably and with reduced discomfort, depending on the region of interest.
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