期刊
HORMONES AND BEHAVIOR
卷 134, 期 -, 页码 -出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.yhbeh.2021.105017
关键词
Stress; Ghrelin; Leptin; GLP-1; Amylin; Energy intake; Food intake
资金
- Clinical and Translational Science Institute Translational Pilot Studies Program through the University at Buffalo (EGM-B)
- NIH National Center for Advancing Translational Sciences [UL1TR001412]
- State University of New York Buffalo State Incentive Funds Program
It is well known that stress can increase total caloric intake, and the hormone ghrelin is the likely candidate driving stress-induced hyperphagia in humans.
It is well known that stress elevates intake of total calories and shifts food preference toward unhealthy food choices. There is, however, little known on the physiological mechanisms that drive stress-induced hyperphagia. In order to better understand how to reduce stress eating, it is critical to identify mechanisms in humans that are points of convergence between stress and eating. The feeding-related hormones ghrelin, leptin, glucagon-like peptide-1 (GLP-1), and amylin are likely candidates. It was hypothesized that ghrelin, an orexigenic hormone, would increase in response to an acute laboratory stressor, but that leptin, GLP-1, and amylin (anorexigenic hormones) would decrease after stress. To this aim, participants (n = 47) came into the laboratory and had feeding-related hormones, salivary cortisol and alpha-amylase, and self-rated anxiety measured. Then they underwent either exposure to a stressor (n = 24), which reliably elevates measures of stress and energy intake, or a nostress condition (n = 23). Feeding hormones, stress hormones, and self-rated anxiety were measured twice more after the stressor. Elevated self-rated anxiety and alpha-amylase confirmed the validity of the stressor. Furthermore, there was a time X condition interaction for both ghrelin and GLP-1. Ghrelin was significantly elevated after stress compared to baseline (p = .02) and there was a trend for GLP-1 to be higher in the stress condition over the no-stress condition immediately after the stressor (p = .07). Overall, ghrelin is the most likely candidate driving energy intake after stress in humans.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据