期刊
HIV MEDICINE
卷 22, 期 8, 页码 705-714出版社
WILEY
DOI: 10.1111/hiv.13117
关键词
antiretroviral therapy; HIV; immune reconstitution inflammatory syndrome; integrase strand transfer inhibitor; tuberculosis
资金
- National Research Foundation of Korea - Korean Government [2019R1I1A3A01058853]
- Chonnam National University Hospital Biomedical Research Institute [BCRI 19032]
- National Research Foundation of Korea [2019R1I1A3A01058853] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
This study investigated the incidence and risk factors of IRIS in Korean HIV patients initiating ART, with an overall IRIS incidence of 9.4% and no association between INSTI treatment and IRIS occurrence.
Objectives Immune reconstitution inflammatory syndrome (IRIS) is a major concern when starting antiretroviral therapy (ART) in patients with advanced HIV infection. The aim of this study was to determine the incidence and risk factors of IRIS in HIV-infected Koreans initiating ART, and whether integrase strand transfer inhibitor (INSTI) treatment increases the risk of IRIS. Methods This retrospective analysis included adults living with HIV, seen at four university-affiliated hospitals in South Korea, who were naive to ART and had a CD4 T-cell count < 200 cells/mu L between January 2004 and May 2019. IRIS was determined through a medical record review within 6 months of ART initiation. Propensity score-matched case-control study between the non-INSTI and INSTI groups was performed. Results The study included 501 patients; 192 were assigned to the INSTI group, who started ART based on INSTIs as the initial treatment. There were opportunistic infections (OIs) in 253 (50.5%) cases before ART initiation. The three most common OIs were Pneumocystis jirovecii pneumonia, candidiasis and tuberculosis (TB). We identified 47 cases of IRIS; TB-IRIS was the most common type. The incidence of IRIS within 6 months of ART initiation was 9.4%, and there were no significant differences in baseline characteristics and incidence of IRIS between the matched groups. The risk factors for IRIS were pre-ART CD4 T-cell count (< 30 cells/mu L), higher pre-ART viral load (>= 75 000 copies/mL), and TB-OI. Conclusions The incidence of IRIS was 9.4% in Korean HIV patients. The INSTI regimen was not related to IRIS occurrence.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据