期刊
HEPATOLOGY INTERNATIONAL
卷 15, 期 5, 页码 1103-1108出版社
SPRINGER
DOI: 10.1007/s12072-021-10235-1
关键词
Tenofovir disoproxil fumarate; Tenofovir alafenamide fumarate; HBV vertical transmission; Pregnant women; Perinatal period; Drug safety
资金
- Sixth People's Hospital of Shenyang
- National Science and Technology Major Special Project for New Drug Development [2018ZX09201016]
The study demonstrated that both TAF and TDF effectively prevented mother-to-child transmission of hepatitis B. TAF showed superiority in terms of renal safety and breastfeeding compared to TDF.
Background Hepatitis B virus (HBV) infection is a significant global health problem and > 42-52% of patients are infected during perinatal period. Tenofovir alafenamide fumarate (TAF) and tenofovir disoproxil fumarate (TDF) have been widely recognized as the main compounds used for antiviral treatment of hepatitis B. The present study evaluated the efficacy and safety of TAF in reducing HBV vertical transmission. Methods A total of 72 pregnant women, who met the inclusion criteria, were randomly divided into the TDF (300 mg/day, n = 36) and TAF (25 mg/day, n = 36) groups. Clinical and laboratory data were analyzed and compared between the two groups. Results No significant differences in alanine aminotransferase, total bilirubin, blood creatinine and blood urea nitrogen levels were noted between the two groups after treatment. The serum HBV DNA viral load and hepatitis B e antigen (HBeAg) levels of the two groups were significantly decreased following treatment, whereas the difference between the two groups was not statistically significant. The levels of urine retinol-binding protein and beta 2-microglobulin had no significant change after TAF treatment (p > 0.05), but increased significantly after TDF treatment (p < 0.05). All drug concentrations were undetectable in umbilical cord blood (UCB) and breast milk samples of the TAF group, while the drug concentration of UCB and breast milk samples in the TDF group was 2.98 +/- 1.44 and 19.16 +/- 15.26 ng/ml, respectively. All infants were tested negative for serum hepatitis B surface antigen, HBV DNA, and HBeAg. Conclusions Both TAF and TDF effectively block the mother-to-child transmission of hepatitis B. TAF was superior to TDF with regard to renal safety and breastfeeding.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据