Hydroalkylation of Styrenes with Benzylamines by Potassium Hydride

A method for the synthesis of 1,3-diarylpropylamines through hydroalkylation of styrenes with benzylamines by potassium hydride has been developed. The protocol is initiated by solvothermal treatment of benzylamines with KH at 100 degrees C to generate deprotonated anionic species, which undergo selective C-alkylation with arylalkenes at 0 degrees C to ambient temperature to afford 1,3-diarylpropylamines as the major product.

Automated summary

A method for the efficient synthesis of 1,3-diarylpropylamines through hydroalkylation of benzylamines and styrenes catalyzed by potassium hydride under solvothermal conditions has been developed.