Sex and Gender Aspects in Vascular Ageing - Focus on Epidemiology, Pathophysiology, and Outcomes

Sex and gender are important modifiers of cardiovascular system physiology, pathophysiology, and disease development. The atherosclerosis process, together with the progressive loss of arterial elasticity with age, is a major factor influencing the development of overt cardiovascular, renal, and cerebrovascular disease. While differences between women and men in epidemiology and pathophysiology of vascular ageing are increasingly reported, sex-disaggregated data are still scarcely available for prospective studies. A better knowledge of sex differences in physiological ageing as well as in disease-related changes in vascular ageing trajectories is crucial to avoid misdiagnosis and mistreatment. This review presents key concepts and knowledge gaps identified in vascular ageing due to gonadal function, vascular physiology, pathophysiology, psychosocial factors, pregnancy, and prognostic relevance. Gender roles determine the effectiveness of any cardiovascular preventive strategy and acceptance for non-invasive or invasive diagnostics and therapeutics. Gender differences in health behaviour, also due to sociocultural norms conditioned by society, contribute to behaviours that may lead to premature arterial vascular ageing. These include differences in risk behaviours like smoking, diet, exercise, and in stress, but also conditions such as housing, noise pollution, poverty, disability, and any kind of stigmatisation. The VascAgeNet Gender Expert Group aims to advance the use of non-invasive vascular ageing measures in routine clinical settings by providing facts to fill in the gaps concerning sex and gender differences at each step of this process, and to search for solutions.

Automated summary

Sex and gender play important roles in cardiovascular system physiology, pathophysiology, and disease development, particularly in the progression of vascular ageing and its impact on cardiovascular, renal, and cerebrovascular diseases. Understanding sex differences in physiological ageing and disease-related changes in vascular ageing trajectories is crucial to avoid misdiagnosis and mistreatment. Gender roles also influence the effectiveness of cardiovascular preventive strategies and acceptance of diagnostic and therapeutic measures, with health behaviors and sociocultural norms contributing to premature arterial vascular ageing. The VascAgeNet Gender Expert Group aims to advance the incorporation of non-invasive vascular ageing measures in routine clinical practices by addressing sex and gender differences and seeking solutions.