Immune response gene coexpression network analysis of Arachis hypogaea infected with Aspergillus flavus

Aspergillus flavus (A. flavus) infection and aflatoxin contamination is a major bottleneck for peanut cultivation and value chain industry. In this study, a transcriptomic network study was conducted by retrieving publically available RNA-seq datasets of resistant and susceptible peanut varieties infected by A. flavus separately to understand the peanut defense mechanism against A. flavus. The gene expression analysis revealed differentially expressed genes (DEGs) in response to the different levels of infection and coexpression network of DEGs deciphered hub genes involved in the immune process in resistant and susceptible varieties. The interplay of resistance conferring genes and cell wall related genes was observed through functional enrichment analysis in response to pathogen infection and identified few key genes such as Protein P21, R genes, Pattern Recognition Receptor genes, Pectinesterases, Laccase and Thaumatin-like protein 1b as candidate genes in imparting immune response against A. flavus.

Automated summary

The study conducted a transcriptomic network analysis to understand the peanut defense mechanism against Aspergillus flavus. Functional enrichment analysis identified key genes involved in immune response against the pathogen, such as Protein P21, R genes, and Pattern Recognition Receptor genes. The interplay of resistance conferring genes and cell wall related genes were observed in response to pathogen infection.