期刊
GENOMICS
卷 113, 期 4, 页码 2605-2613出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ygeno.2021.06.007
关键词
Primates; Blood; Sex-specific expression; X-Y gene pair; MSY gene
资金
- Sichuan Science and Technology Program [2020YJ0303]
- National Natural Science Foundation of China [32070413]
The study revealed sex-specific gene expression differences in the blood tissues of four primates, with 31 sex-specific differentially expressed genes identified in humans. Most XY gene pairs had similar expression levels between species, except for one pair (EIF1AY/EIF1AX). Humans had significant XY-biased and XX-biased X-Y gene pairs, while rhesus and Tibetan macaques did not show significant differential expression levels in their X-Y gene pairs.
Blood is an important non-reproductive tissue, but little is known about the sex-specific gene expressions in the blood. Therefore, we investigated sex-specific gene expression differences in the blood tissues of four primates, rhesus macaques (Macaca mulatta), Tibetan macaques (M. thibetana), yellow baboons (Papio cynocephalus), and humans. We identified seven sex-specific differentially expressed genes (SDEGs) in each non-human primate and 31 SDEGs in humans. The four primates had only one common SDEG, MAP7D2. In humans, immune-related SDEGs were identified as up-regulated, but also down-regulated in females. We also found that most of the XY gene pairs had similar expression levels between species, except pair EIF1AY/EIF1AX. The expression level of X-Y gene pairs of rhesus and Tibetan macaques showed no significant differential expression levels, while humans had six significant XY-biased and three XX-biased X-Y gene pairs. Our observed sex differences in blood should increase understanding of sex differences in primate blood tissue.
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