期刊
FUTURE MEDICINAL CHEMISTRY
卷 13, 期 21, 页码 1833-1843出版社
Newlands Press Ltd
DOI: 10.4155/fmc-2021-0098
关键词
drug delivery; hyperthermia; iron oxide nanoparticles; minocycline; PLGA scaffolds
资金
- National Institute of General Medical Sciences of the National Institutes of Health [SC3GM135138]
- National Science Foundation (NSF) PREM [DMR-1523577]
- University of Texas Rio Grande Valley Mathematics and Science Academy High Scholars Program
This study demonstrates the potential of iron oxide nanoparticles (Fe3O4 NPs) for controlling minocycline release from polymeric scaffolds via magnetic hyperthermia, with higher concentrations of nanoparticles leading to greater heat generation and drug release. Elevated temperature and minocycline release from the scaffold can work synergistically to enhance glioblastoma cell death.
Background: The utilization of iron oxide nanoparticles (Fe3O4 NPs) to control minocycline release rates from poly(lactic-co-glycolic acid) scaffolds fabricated from an easy/economical technique is presented. Results/Methodology: A larger change in temperature and amount of minocycline released was observed for scaffolds with higher amounts of Fe3O4 NPs, demonstrating that nanoparticle concentration can control heat generation and minocycline release. Temperatures near a polymer's glass transition temperature can result in the polymer's chain becoming more mobile and thus increasing drug diffusion out of the scaffold. Elevated temperature and minocycline released from the scaffold can work synergistically to enhance glioblastoma cell death. Conclusion: This study suggests that Fe3O4 NPs are promising materials for controlling minocycline release from polymeric scaffolds by magnetic hyperthermia for the treatment of glioblastoma.
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