期刊
FUTURE MEDICINAL CHEMISTRY
卷 13, 期 20, 页码 -出版社
FUTURE SCI LTD
DOI: 10.4155/fmc-2021-0176
关键词
Alzheimer's disease; antioxidants; calcium channel blockers; cholinesterase inhibitors; Hantzsch multicomponent reaction
资金
- Regional Council of Franche-Comte PRIME [2016YC-04540, 04560]
This study synthesized twelve new compounds and evaluated their Ca2+ channel blockade capacity, cholinesterase inhibition, and antioxidant power. Results showed that one of the compounds has the potential for Alzheimer's disease therapy.
Background: Alzheimer's disease is a chronic neurodegenerative chronic disease with a heavy social and economic impact in our developed societies, which still lacks an efficient therapy. Method: This paper describes the Hantzsch multicomponent synthesis of twelve alkyl hexahydro-quinoline-3-carboxylates, 4a-l, along with the evaluation of their Ca2+ channel blockade capacity, cholinesterase inhibition and antioxidant power. Results: Compound 4l showed submicromolar inhibition of butyrylcholinesterase, Ca2+ channel antagonism and an antioxidant effect. Conclusion: Compound 4l is an interesting compound that deserves further investigation for Alzheimer's disease therapy.
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