期刊
FIBERS AND POLYMERS
卷 17, 期 11, 页码 1835-1841出版社
KOREAN FIBER SOC
DOI: 10.1007/s12221-016-6716-0
关键词
Polyvinyl alcohol-styrylpyridinium; beta-cyclodextrin; Electrospinning; Mechanical properties; Drug release
资金
- Priority Academic Program Development of Jiangsu Higher Education Institutions
- National Natural Science Foundation of China [51203064, 21201083]
- Natural Science Foundation of Jiangsu Province
- Industry-Academia-Research Joint Innovation Fund of Jiangsu Province [BY2014023-4, BY2014023-23, BY2014023-29]
- Six talent peaks project in Jiangsu Province [2014-XCL001]
- China PostdoCtoral Science Foundation [2014M560391, 2015T80496]
Biocompatible polyvinyl alcohol (PVA)-styrylpyridinium (SbQ)/beta-cyclodextrin (beta-CD) composite nanofibers were obtained by electrospinning in this study. PVA-SbQ was used as the foundation polymer as well as crosslinking agent, beta-CD was incorporated to achieve expected properties such as improved mechanical properties and thermal stability. The Fourier transform infrared spectroscopy (FTIR) spectra confirmed the existence of beta-CD, and the morphologies and average fiber diameters of the electrospun composite nanofibers were also analyzed by SEM. X-ray diffraction patterns (XRD) of PVA-SbQ/beta-CD composite nanofibers revealed that the inclusion of beta-CD in the nanofibers affected the ordered phase of PVA. Besides, the thermal analyses revealed the improvement in the thermal properties for PVA-SbQ/beta-CD composite nanofibers. It was found that the crosslinked composite nanofibers showed a clear higher tensile strength (TS) as well as a greater elongation at break (EB). Eventually, antifungal drug griseofulvin (GSV) has been loaded into the composite nanofibers by formation of its inclusion complex with beta-CD in aqueous solution, ultraviolet light (UV-Vis) spectral analysis showed that the drug-loading nanofibers had certain sustained release effect.
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