期刊
FRONTIERS IN HUMAN NEUROSCIENCE
卷 15, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fnhum.2021.645584
关键词
deep brain stimulation; nucleus basalis of Meynert; Alzheimer's disease; thermoregulatory disturbance; Mini-Mental State Examination
资金
- National Nature Science Foundation of China [61761166004, 81701268, 81970992]
- National Key Research and Development Program of China [2016YFC1306300]
- National Key R&D Program of China-European Commission [2017YFE0118800-779238]
- Project for the Scientific and Technological Development of Traditional Chinese Medicine in Beijing, China [JJ2018-48]
NBM-DBS has been reported to improve cognitive function in individuals with severe AD. A study on an 80-year-old male subject showed significant improvements in MMSE and ADAS-cog assessments after 10 weeks of stimulation. Despite postoperative complications, the patient fully recovered, indicating that NBM-DBS may be a potential therapy for severe AD patients.
Patients with advanced Alzheimer's disease (AD) experience cognitive impairment and physical disabilities in daily life. Currently, there are no treatments available to slow down the course of the disease, and limited treatments exist only to treat symptoms. However, deep brain stimulation of the nucleus basalis of Meynert (NBM-DBS) has been reported to improve cognitive function in individuals with AD. Here, we report the effects of NBM-DBS on cognitive function in a subject with severe AD. An 80-year-old male with severe AD (Clinical Dementia Rating scale: 3.0 points) underwent surgery for bilateral NBM-DBS electrode placement. After 10 weeks of stimulation, Mini-Mental State Examination (MMSE) assessment improved from a score of 5 to 9 points, and assessment using the Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-cog) showed a marked reduction in total score from 43 to 33 points, suggesting cognitive benefits from NBM-DBS. The patient's postoperative course was complicated by a subdural effusion that occurred several days after surgery, with complete recovery. Interestingly, the subject also displayed abnormal thermoregulation with stimulation initiation and stimulation parameter modifications. NBM-DBS may serve as a potential therapy for severe AD patients.
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