Voxel-Wise Analysis of Structural and Functional MRI for Lateralization of Handedness in College Students

The brain structural and functional basis of lateralization in handedness is largely unclear. This study aimed to explore this issue by using voxel-mirrored homotopic connectivity (VMHC) measured by resting-state functional MRI (R-fMRI) and gray matter asymmetry index (AI) by high-resolution anatomical images. A total of 50 healthy subjects were included, among them were 13 left-handers, 24 right-handers, and 13 mixed-handers. Structural and R-fMRI data of all subjects were collected. There were significant differences in VMHC among the three groups in lateral temporal-occipital, orbitofrontal, and primary hand motor regions. Meanwhile, there were significant differences in AI that existed in medial prefrontal, superior frontal, and superior temporal regions. Besides, the correlation analysis showed that the closer the handedness score to the extreme of the left-handedness (LH), the stronger the interhemispheric functional connectivity, as well as more leftward gray matter. In general, left/mixed-handedness (MH) showed stronger functional homotopy in the transmodal association regions that depend on the integrity of the corpus callosum, but more variable in primary sensorimotor cortices. Furthermore, the group differences in VMHC largely align with that in AI. We located the specific regions for LH/MH from the perspective of structural specification and functional integration, suggesting the plasticity of hand movement and different patterns of emotional processing.

Automated summary

This study investigated the structural and functional basis of handedness lateralization in the brain using resting-state functional MRI (R-fMRI) and gray matter asymmetry index. The results showed significant differences in voxel-mirrored homotopic connectivity (VMHC) and gray matter asymmetry (AI) among left-handers, right-handers, and mixed-handers. Left/mixed-handedness individuals exhibited stronger functional homotopy in transmodal association regions and more variability in primary sensorimotor cortices. The study suggests plasticity of hand movement and different patterns of emotional processing.