4.7 Article

Dietary rational targeting of redox-regulated genes

期刊

FREE RADICAL BIOLOGY AND MEDICINE
卷 173, 期 -, 页码 19-28

出版社

ELSEVIER SCIENCE INC
DOI: 10.1016/j.freeradbiomed.2021.07.021

关键词

Redox; Gene expression; Diet; Precision nutrition; Oxidative stress; Human; Health; Fruits and vegetables; Nutrigenomics

资金

  1. Bender Scientific Fund
  2. Wildermuth Foundation

向作者/读者索取更多资源

Nutrigenomics is the study of how food and nutrients impact gene expression, aiming to design precision nutrition strategies for human health. Modulation of redox-associated genes through healthy diet can treat diseases, reduce treatment costs, and improve health outcomes, with potential clinical significance.
Nutrigenomics is the study of how food and associated nutrients affect gene expression. This field sits at the intersection of diet, the genome and health with the ultimate goal of exploiting its understanding to design a precision nutrition strategy for humans. We have studied diet and nutrigenomics in the context of something we call dietary rational gene targeting. Here, healthy diet is used to alter disease-causing gene expression back toward the normal to treat various diseases and conditions while lowering treatment cost and toxicity. In this paper, we discuss the use of this strategy to modulate the expression of redox-associated genes to improve human health. Most human disorders are associated, at least to some extent, with oxidative stress and so treatments (including diet) that target redox-related genes have major potential clinical significance. Healthy dietary op-tions here are wide-ranging and include whole foods and botanical-based beverages. In some cases, botanical supplements may also be useful gene modulators although their health benefits are less clear. Key redox gene targets for these dietary agents include antioxidant genes, related transcription factors, detoxification genes, and DNA repair genes. Other important considerations include bioavailability, the contribution of the microbiome, and advancing technologies. In this review, specific examples of redox associated genes and pathologies and their potential treatment with healthy diet are presented to illustrate our approach. This will also serve as a foundation for the design of future clinical studies to improve diet-related health.

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