Oxidative stress in anticancer therapies-related cardiac dysfunction

Redox abnormalities are at the crossroad of cardiovascular diseases, cancer and cardiotoxicity from anticancer treatments. Indeed, disturbances of the redox equilibrium are common drivers of these conditions. Not only is an increase in oxidative stress a fundamental mechanism of action of anthracyclines (which have historically been the most studied anticancer treatments) but also this is at the basis of the toxic cardiovascular effects of antineoplastic targeted drugs and radiotherapy. Here we examine the oxidative mechanisms involved in the different cardiotoxicities induced by the main redox-based antineoplastic treatments, and discuss novel approaches for the treatment of such toxicities.

Automated summary

Redox abnormalities play a significant role in cardiovascular diseases, cancer, and cardiotoxicity from anticancer treatments. Increased oxidative stress is a key mechanism of action for anthracyclines and is also responsible for the toxic cardiovascular effects of antineoplastic targeted drugs and radiotherapy.