4.7 Review

Impact of food-derived bioactive peptides on gut function and health

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The effects of diet and gut microbiota on the regulation of intestinal mucin glycosylation

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Summary: The review discusses the regulation of intestinal mucins glycosylation by host cues and environmental signals, particularly from the microbiome and diets. It summarizes the dynamic alterations of mucin glycosylation induced by immune responses to gut diseases and identifies mechanisms of how dietary components affect intestinal mucin glycosylation and maintain mucosal homeostasis. The review also proposes a potential framework for individualized dietary recommendations to prevent abnormal mucin glycosylation driven by immune dysregulation, gut microbiome alterations, and other factors.

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