期刊
FOOD CHEMISTRY
卷 347, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2021.129002
关键词
Magnetic solid-phase extraction; Covalent organic frameworks; Non-steroidal anti-inflammatory drug; Diclofenac sodium; Sample pretreatment
资金
- National Natural Science Foundation of China [21806148]
- Fundamental Research Funds for the Central Universities, China University of Geosciences (Wuhan) [CUG170102, CUG180610]
A robust MSPE method based on MCOF coupled with HPLC-UV/MS was proposed for the determination of trace DS in milk. The method showed high accuracy and a low detection limit of 10 ng/kg, demonstrating its potential for monitoring trace pharmaceutical contaminants in real food samples.
A robust magnetic solid-phase extraction (MSPE) method based on magnetic covalent organic framework (MCOF) coupled with high-performance liquid chromatography (HPLC)-ultraviolet (UV)/mass spectrometry (MS) was proposed for the determination of trace diclofenac sodium (DS) in milk. The prepared MCOF exhibited high extraction efficiency, which can be attributed to its high specific surface area as well as strong 7C-7C and hydrophobic interactions between MCOF and DS. In addition, the potential influencing factors, including sample volume, adsorbent dosage, extraction time, and elution parameters, were fully estimated. The experimental results demonstrated that the established method was sensitive for the quantification of DS with high accuracy. Remarkably, the detection limit of DS was found to be 10 ng/kg under the optimal conditions. More impressively, the developed method was successfully applied to monitor trace DS in milk, demonstrating its outstanding durability and practical potential as an appealing method to regular monitor trace pharmaceutical contaminants in real food samples.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据