4.7 Article

Determination and risk assessment of acrylamide in thermally processed Atractylodis Macrocephalae Rhizoma

期刊

FOOD CHEMISTRY
卷 352, 期 -, 页码 -

出版社

ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2021.129438

关键词

Acrylamide; GMWCNTs; Atractylodis Macrocephalae Rhizoma; Thermal processing

资金

  1. Zhejiang Medical Science and Technology Program [2020RC085]
  2. Scientific Research funding of Zhejiang Chinese Medical University [2019ZR21, 2019ZR20, 2019ZG42]
  3. Zhejiang Traditional Chinese Medicine Scientific Research Program [2021ZQ024, 2020ZQ013]
  4. Research Project of Zhejiang Education Department [Y202045160]
  5. Zhejiang Provincial Natural Science of Foundation of China [LQ20B070005]

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A method was developed to determine acrylamide in Atractylodis Macrocephalae Rhizoma (AMR), revealing a significant increase in acrylamide concentration in AMR after thermal processing, which poses a high health risk.
As one of the medicine homologous foods in China, Atractylodis Macrocephalae Rhizoma (AMR) is usually distributed after thermal processing, which raised the possibility of acrylamide pollution and a potential carcinogenic risk. In this study, a method was developed for the determination of the acrylamide in AMR using graphited multiwalled carbon nanotubes as the dispersive solid phase extraction sorbent and liquid chromatography tandem mass spectrometry. The concentration of acrylamide was investigated at processing conditions of 80 degrees C-210 degrees C. and 5 min-100 min. Method validation results demonstrated the reliability of the method with good linearity, accuracy and precision. Significant increment of acrylamide was found in AMR after thermal processing with the highest concentration at 9826 mu g/kg, which led to a margin of exposure at 90.83-181.7 according to the BMDL10 of carcinogenicity at 0.17 mg/kg, indicating a high health risk of taking thermally processed AMR, and monitoring and controlling should be considered.

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