期刊
FOOD AND CHEMICAL TOXICOLOGY
卷 153, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fct.2021.112251
关键词
Mycotoxin; Epigenetic alterations; DNA methylation; Non-coding RNAs; Protein post-translational modification
资金
- China National Postdoctoral Program for Innovative Talents [BX20190375]
- Shandong Major Scientific and Technological Innovation Projects [2019JZZY011014]
- China Agricultural University
This review summarizes the epigenetic alterations induced by mycotoxins, including DNA methylation, non-coding RNAs, and protein post-translational modifications, after mycotoxin exposure. It also discusses the deficiencies in research methods and provides some remedial suggestions to better understand the non-genotoxic effects of mycotoxins.
Mycotoxins contaminate all types of food and feed, threatening human and animal health through food chain accumulation, producing various toxic effects. Increasing attention is being focused on the molecular mechanism of mycotoxin-induced toxicity in all kinds of in vivo and in vitro models. Epigenetic alterations, including DNA methylation, non-coding RNAs (ncRNAs), and protein post-translational modifications (PTMs), were identified as being involved in various types of mycotoxin-induced toxicity. In this review, the emphasis was on summarizing the epigenetic alterations induced by mycotoxin, including aflatoxin B1 (AFB1), ochratoxin A (OTA), zearalenone (ZEA), fumonisin B1 (FB1), and deoxynivalenol (DON). This review summarized and analyzed the roles of DNA methylation, ncRNAs, and protein PTMs after mycotoxin exposure based on recently published papers. Moreover, the main research methods and their deficiencies were determined, while some remedial suggestions are proposed. In summary, this review helps to understand better the epigenetic alterations induced by the non-genotoxic effects of mycotoxin.
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