期刊
FOOD AND CHEMICAL TOXICOLOGY
卷 153, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fct.2021.112240
关键词
Wheat embryo globulin; Alcoholic liver disease; Hepatoprotective effect; Oxidative stress; Gut microbiota
资金
- Zhongyuan Scholars of Henan Province in China [192101510004]
- Strategic Consulting Research Project of Henan Institute of Chinese Engineering Development Strategies [2020HENZT13]
- Major Science and Technology Projects for Public Welfare of Henan Province [201300110300]
- Youth Talent Support Program of Henan Province in China [2018HYTP014]
- Key Project Foundation of Natural Science Research of Universities of Henan Province in China [20A550004]
- Key Scientific and Technological Research Projects of Henan Province [202102310518]
- Fundamental Research Funds for the Henan Provincial Colleges and Universities in Henan University of Technology (HAUT)
- High-Level Talents Research Fund of HAUT [2018QNJH13, 2018BS012]
- Open Research Subject of National Engineering Laboratory for Wheat & Corn Further Processing [NL2020002]
Wheat Embryo Globulin (WEG) is a plant-derived protein with anti-inflammatory, antioxidant, and immunity enhancement effects. Experimental results showed that WEG can significantly alleviate acute alcoholic liver injury and have a positive impact on liver and intestinal health.
Wheat Embryo Globulin (WEG) is a high-quality plant-derived protein with anti-inflammatory, antioxidant, and immunity enhancement effects. WEG was prepared and characterized using free amino acid analysis, circular dichroism (CD), and scanning electron microscope (SEM). The liver protection effect of WEG on mice after acute alcohol stimulation was also investigated. Male KM mice were randomly divided into four groups (n = 10). Animals were orally administrated with WEG (60 mg/kg), silymarin (50 mg/kg), and the same volume of saline solution daily for 30 days, before administering an alcohol-intragastric injection. Results displayed that the liver index, the levels of serum total cholesterol (TC), serum triglyceride (TG), liver malondialdehyde (MDA) and the mRNA expression of CYP2E1were significantly decreased in WEG-treated mice compared with the model group. Meanwhile, the levels of serum high-density lipoprotein-cholesterol (HDL-C), hepatic reduced glutathione (GSH), superoxide dismutase (SOD) and the mRNA expression of ADH(2) and ALDH(2) were remarkably increased. Effect of WEG on histopathology of liver tissue confirmed its protective function. Meanwhile, GSH level of ileal was significantly increased, MDA was remarkably decreased in WEG-treated mice, which also indicated that WEG possessed a positive effect on intestinal micro ecological environment health to some extent. In conclusion, WEG is a promising agent for the prevention of acute alcoholic liver injury.
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