4.7 Article

Empagliflozin and neohesperidin protect against methotrexate-induced renal toxicity via suppression of oxidative stress and inflammation in male rats

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Pharmacology & Pharmacy

Empagliflozin prevents from early cardiac injury post myocardial infarction in non-diabetic mice

Yihai Liu et al.

Summary: The study demonstrated that the SGLT2 inhibitor empagliflozin could improve cardiac remodeling in early myocardial infarction of non-diabetic mice by reducing cardiomyocyte apoptosis, oxidative stress, and restoring mitochondrial membrane potential. The activation of AMP-activated protein kinase (AMPK) signaling pathway may mediate the cardioprotective role of empagliflozin.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2021)

Article Medicine, Research & Experimental

Cilostazol mitigates mesenteric ischemia/reperfusion-induced lung lesion: Contribution of PPAR-γ, NF-κB, and STAT3 crosstalk

Abdallah M. Gendy et al.

Summary: Cilostazol, a phosphodiesterase-III inhibitor, has been shown to have protective effects against intestinal ischemia/reperfusion-induced lung injury, partly by modulating oxidative stress, inflammation, and apoptosis mechanisms.

LIFE SCIENCES (2021)

Article Oncology

Bexarotene inhibits cell proliferation by inducing oxidative stress, DNA damage and apoptosis via PPARγ/ NF-κB signaling pathway in C6 glioma cells

Ceyhan Hacioglu et al.

Summary: Bexarotene treatment showed concentration- and time-dependent anti-proliferative effects on C6 glioma cells by modulating apoptosis profile, DNA damage, reactive oxygen species production, and reducing total antioxidant levels through the inhibition of NF-kappa B by enhancing PPAR gamma expression.

MEDICAL ONCOLOGY (2021)

Article Medicine, Research & Experimental

被撤回的出版物: Empagliflozin and neohesperidin mitigate methotrexate hepatotoxicity via Nrf2/PPARγ/HO-1 signalling initiation and suppression of NF-κB/Keap1/HSP70/caspase-3 axis in rats (Retracted article. See vol. 294, 2022)

Adel T. Osman et al.

Summary: The study demonstrated that EMPA and NHD have protective effects on MTX-induced liver injury by modulating multiple signaling pathways, enhancing anti-tumor activity, and potentially delaying the onset of toxicity.

LIFE SCIENCES (2021)

Article Biochemistry & Molecular Biology

Neohesperidin alleviated pathological damage and immunological imbalance in rat myocardial ischemia-reperfusion injury via inactivation of JNK and NF-κB p65

Aihua Li et al.

Summary: Neohesperidin (NEO) mitigates myocardial ischemia-reperfusion (I/R) injury by inhibiting inflammation, oxidative stress, and cell apoptosis, making it a potential therapeutic agent for myocardial I/R therapy.

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY (2021)

Article Biochemistry & Molecular Biology

Dissection of the potential pharmacological function of neohesperidin dihydrochalcone - a food additive - by in vivo substances profiling and network pharmacology

Feng-Xiang Zhang et al.

Summary: Food additives have gained extensive attention worldwide due to their side-effects. This study utilized a combination of metabolite profiling and network pharmacology to characterize the metabolic features of neohesperidin dihydrochalcone (NHDC) and reveal its pharmacological changes. The results showed that NHDC undergoes hydrolysis and conjugation reactions in vivo, with its metabolites involved in various pathways, suggesting potential novel functions or side-effects.

FOOD & FUNCTION (2021)

Article Pharmacology & Pharmacy

Protective effects of hesperidin against MTX-induced hepatotoxicity in male albino rats

Ramadan M. Abdelaziz et al.

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2020)

Article Pharmacology & Pharmacy

Empagliflozin ameliorates endothelial dysfunction and suppresses atherogenesis in diabetic apolipoprotein E-deficient mice

Byambasuren Ganbaatar et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2020)

Article Cardiac & Cardiovascular Systems

SGLT2 inhibition with empagliflozin attenuates myocardial oxidative stress and fibrosis in diabetic mice heart

Chenguang Li et al.

CARDIOVASCULAR DIABETOLOGY (2019)

Article Pharmacology & Pharmacy

Crocin ameliorates methotrexate-induced liver injury via inhibition of oxidative stress and inflammation in rats

Mojtaba Kalantar et al.

PHARMACOLOGICAL REPORTS (2019)

Article Cardiac & Cardiovascular Systems

Empagliflozin Improves Kidney Outcomes in Patients With or Without Heart Failure Insights From the EMPA-REG OUTCOME Trial

Javed Butler et al.

CIRCULATION-HEART FAILURE (2019)

Review Biochemistry & Molecular Biology

Heat Shock Proteins: Dynamic Biomolecules to Counter Plant Biotic and Abiotic Stresses

Saeed ul Haq et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Medicine, Research & Experimental

Early administration of empagliflozin preserved heart function in cardiorenal syndrome in rat

Chih-Chao Yang et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

Review Biochemistry & Molecular Biology

Dihydrochalcones: Methods of Acquisition and Pharmacological Properties-A First Systematic Review

Monika Stompor et al.

MOLECULES (2019)

Article Medicine, Research & Experimental

Biochemical investigation of gender-specific association between insulin resistance and inflammatory biomarkers in types 2 diabetic patients

Muhammad Sajid Hamid Akash et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

Review Cardiac & Cardiovascular Systems

Potential mechanisms responsible for cardioprotective effects of sodium-glucose co-transporter 2 inhibitors

Sarayut Lahnwong et al.

CARDIOVASCULAR DIABETOLOGY (2018)

Article Biochemistry & Molecular Biology

N-Acetylcysteine as an antioxidant and disulphide breaking agent: the reasons why

Giancarlo Aldini et al.

FREE RADICAL RESEARCH (2018)

Article Oncology

Caspase-3 regulates the migration, invasion and metastasis of colon cancer cells

Min Zhou et al.

INTERNATIONAL JOURNAL OF CANCER (2018)

Article Pathology

Method for the measurement of antioxidant activity in human fluids

D Koracevic et al.

JOURNAL OF CLINICAL PATHOLOGY (2001)