期刊
FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT
卷 38, 期 8, 页码 1416-1426出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/19440049.2021.1922758
关键词
Dioxins; breastmilk; primipara; estimated daily intake
资金
- Universiti Sains Malaysia [RUI grant] [1001/CAATS/812172]
- Fundamental Research Grant Scheme (FRGS) [203/CRACUN/6711537]
The research found that lactating first-time mothers in Penang Island, Malaysia had relatively low levels of toxic substances, but there is still a risk of exposure to infants. Particularly in the Penang region, levels of dioxins and dl-PCBs in breast milk were closely related to years of residence.
An average 50 ml breast milk samples were collected from 21 lactating primiparous mothers (range 25 to 45 years, mean 33 years), 4-8 weeks after delivery in Penang Island, Malaysia. The geometric mean concentration of the most toxic congeners, 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD) was 0.14 pg WHO2005-TEQ g(-1) zlipid. The most abundant congeners of PCDD/Fs were octachlorodibenzo-p-dioxin (OCDD) (5.9-75.4%), followed by 1,2,3,4,6,7,8-heptachlorodibenzo-p-dioxin (1,2,3,4,6,7,8-HpCDD) (1.1-30.7%). The geometric mean level of total dioxins and dl-PCBs was 2.2 pg WHO2005-TEQ g(-1) lipid, significantly lower than those in developed countries or highly contaminated areas. The total dioxins and dl-PCBs in pg WHO2005-TEQ levels in breast milk were significantly correlated with years of residence at potential contaminated site. The average daily intake of 11.8 pg WHO2005-TEQ kg(-1) body weight was estimated for a breastfed infant at 6 months of age. This demonstrates the exposure risk to infants, especially from Penang region, to these pollutants from human milk intake are potentially high during the lactation period.
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