Polyprenylated acylphloroglucinol meroterpenoids with PTP1B inhibition from Hypericum forrestii

Three new polyprenylated acylphloroglucinol meroterpenoids, hyperiforins A-C (1-3), were isolated from Hypericum forrestii (Chittenden) N. Robson, together with twelve known analogues (4-15). Their structures were established by extensive physical and spectroscopic data analysis. Compounds 1, 2, 5, 7, and 13-15 showed potent inhibitory effects on protein tyrosine phosphatase 1B with IC50 values from 6.63 +/- 2.40 to 14.21 +/- 3.51 is mu M.

Automated summary

Three new polyprenylated acylphloroglucinol meroterpenoids, hyperiforins A-C, were isolated from Hypericum forrestii, along with twelve known analogues. Among them, compounds 1, 2, 5, 7, and 13-15 exhibited potent inhibitory effects on protein tyrosine phosphatase 1B with IC50 values ranging from 6.63 +/- 2.40 to 14.21 +/- 3.51 μM.