期刊
FITOTERAPIA
卷 152, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.fitote.2021.104939
关键词
Roots of Schisandra chinensis; Schisandraceae; Triterpene; Non-medicinal part; Schinensins A-D
资金
- JSPS KAKENHI [JP20K07113]
A phytochemical study on the roots of Schisandra chinensis, a non-medicinal part used in herbal medicine, isolated five new triterpenes and 21 known compounds. Some of the triterpenes showed significant antiproliferative activities against human breast carcinoma MCF-7 cells compared to other cell lines.
Phytochemical study on a non-medicinal part of a plant material for herbal medicine, the roots of Schisandra chinensis, was conducted to isolate five new triterpenes, schinensins A-D (1-4) and 3-O-methylchangnanic acid (5), together with 21 known compounds including 10 triterpenes, one sterol, two sesquiterpenes, seven lignans, and one flavonoid. The structures of new triterpenes (1-5) were assigned on the basis of spectroscopic analyses aided with TDDFT ECD calculations. Schinensin A (1) was a dinortriterpene possessing 28-norschiartane skeleton, while schinensins B-D (2-4) were assigned as 3,4:9,10-disecocycloartane, 3,4-secocycloartane, and cycloartane triterpenes, respectively. In an evaluation of antiproliferative activities against human cancer cell lines, some triterpenes exhibited significant activities against human breast carcinoma MCF-7 cells as compared to the other cell lines (A549, HeLa, and RPMI8226).
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