期刊
FITOTERAPIA
卷 152, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.fitote.2021.104942
关键词
Pterodontic acid; Pterodontic acid derivatives; Antiviral activity; Antiviral therapy index; Laggera pterodonta (DC; )
资金
- national natural science foundation of China [81960666]
- NSFC-Yunnan United fund [U1502226]
- Program Innovative Research Team in Science and Technology in Yunnan Province [2020HC008]
- Yunnan scholar of Yunling [YNWR-YLXZ-2019-019]
- Special projects in Yunnan Province [202002AA100007, 202005AE160004]
- Science and technology project in Kunming [2020-1-N-047]
- Key Projects of Yunnan Province [2019FA033]
Laggera pterodonta is a folk herb widely distributed in southwest China, showing anti-pathogenic microorganisms and anti-inflammatory properties. The synthesis of pterodontic acid derivatives and evaluation of their anti-influenza A virus activities have potential clinical significance for the treatment of respiratory viral diseases.
Laggera pterodonta (DC.) Benth, a folk herb widely distributes in southwest China, especially in Yunnan Province, demonstrates anti-pathogenic microorganisms, anti-inflammatory, inhibition of Helicobacter pylori activities in vitro et al. Interestingly, previous studies have shown that pterodontic acid (1), a eudesmane-type sesquiterpene isolated from L. pterodonta (DC.), displays excellent selective antiviral activity to H1N1 subtype of influenza A virus. At the same time, our group also discovered that the antiviral activity of 1 was relatively close to that activity of post-marketed ribavirin. Therefore, we consider that the synthesis of pterodontic acid (1) derivatives and evaluation of their anti-influenza A virus (H1N1) activities is of potential clinical significance. In this manuscript, a series of pterodontic acid derivatives were prepared and demonstrated significantly improved antiinfluenza A virus (H1N1) activities, providing more opportunities for the treatment of respiratory viral diseases.
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