4.6 Article

A newly identified polyunsaturated macamide alleviates dextran sulfate sodium-induced colitis in mice

期刊

FITOTERAPIA
卷 152, 期 -, 页码 -

出版社

ELSEVIER
DOI: 10.1016/j.fitote.2021.104916

关键词

Macamide; Docosahexaenoic acid; Ulcerative colitis; Cytokine; Tight junction; N-Benzyl docosahexaenamide

资金

  1. National Natural Science Foundation of China [81770527]
  2. Special Foundation of Public Welfare Research and Capacity Building of Guangdong Province [2017A020214020]
  3. Natural Science Foundation of Hunan Province [2019JJ40256]

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A newly identified macamide, NB-DHA, with the highest degree of unsaturation among all identified macamides was discovered in maca extract. Studies showed that NB-DHA significantly alleviated colitis-induced symptoms and could potentially be developed as a therapeutic agent for ulcerative colitis.
Macamides are a class of bioactive amide alkaloids found only in maca (Lepidium meyenii). Recent studies have shown that macamide-rich extracts possess various biological activities, such as antioxidative, immuneenhancing, and reproductive health-improving activities. In the present study, N-benzyl docosahexaenamide (NB-DHA), a newly identified macamide with the highest degree of unsaturation among all identified macamides, was identified from the maca extract. Microalgae oil, a docosahexaenoic acid-rich substance, was used as the starting material for the synthesis of NB-DHA. The effects of NB-DHA in colitis-induced mice were evaluated. NB-DHA significantly alleviated weight loss, shortening of colon length, and occult blood occurrence in mice with dextran sulfate sodium-induced colitis. Histological analysis revealed that following the administration of NB-DHA in mice with colitis, the infiltration of inflammatory cells and levels of proinflammatory factors, such as tumor necrosis factor-alpha, interleukin (IL)-1 beta, IL-6, and myeloperoxidase, decreased, whereas the level of the antiinflammatory factor IL-10 increased. Furthermore, the decreased expression of intestinal tight junction proteins caused by colitis was upregulated by the administration of NB-DHA. These results indicate that NB-DHA could be developed as a therapeutic agent for ulcerative colitis.

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