期刊
FETAL DIAGNOSIS AND THERAPY
卷 48, 期 9, 页码 660-666出版社
KARGER
DOI: 10.1159/000517800
关键词
Twin-twin transfusion syndrome; Fetoscopic laser surgery; Placental abruption
The study compared the rate of placental abruption in TTTS treated with selective laser technique and Solomon laser technique, finding a low rate of placental abruption which was associated with lower gestational age at birth and severe cerebral injury. The use of the Solomon technique did not significantly increase the rate of placental abruption. Continued research is needed to determine why the rate of placental abruption in TTTS is higher than in the overall population.
Introduction: Twin-twin transfusion syndrome (TTTS) is a complication in monochorionic twin pregnancies which is preferably treated with fetoscopic laser surgery. A few small studies suggested a possible association between the Solomon laser technique and placental abruption. Methods: The objective of this study is to compare the rate of and to explore potential risk factors for placental abruption in TTTS treated with fetoscopic laser surgery according to the Selective and Solomon laser technique. We conducted a large retrospective cohort study of consecutive TTTS-cases treated with fetoscopic laser surgery in Shanghai, China, and Leiden, The Netherlands treated with either the Selective laser technique (Selective group) or Solomon laser technique (Solomon group). Results: The rate of placental abruption in the Selective group versus the Solomon group was 1.7% (5/289) and 3.4% (15/441), respectively (p = 0.184). No risk factors for placental abruption were identified. Placental abruption was associated with lower gestational age at birth (p = 0.003) and severe cerebral injury (p = 0.003). Conclusion: The prevalence of placental abruption in TTTS after fetoscopic laser surgery is low, although it appears higher than in the overall population. Placental abruption is associated with a lower gestational age at birth, which is associated with severe cerebral injury. The rate of placental abruption was not significantly increased with the use of the Solomon technique. Continued research of placental abruption in TTTS is necessary to determine why the rate is higher than in the overall population.
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