期刊
FERTILITY AND STERILITY
卷 116, 期 5, 页码 1205-1211出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.fertnstert.2021.06.027
关键词
Blastocyst; mosaicism; preimplantation genetic testing
Preimplantation genetic testing for aneuploidy (PGT-A) remains a controversial topic in reproductive medicine, with ongoing misconceptions and misinterpretations surrounding genetic analysis and prediction of mosaicism in preimplantation embryos.
Preimplantation genetic testing for aneuploidy (PGT-A) remains one of the most controversial topics in reproductive medicine. With more than 40% of in vitro fertilization cycles in the United States reportedly involving PGT, both those in favor of and those opposed to PGT-A have significant interest in the efficacy of PGT-A. Ongoing issues include what patient population, if any, benefits from PGT-A, the true frequency of chromosomal mosaicism, whether embryonic aneuploidies self-correct, and how practitioners manage embryos designated as mosaic.This review addresses several misconceptions and misinterpretations of data surrounding the genetic analysis and prediction of mosaicism in the preimplantation embryo. ((C) 2021 by American Society for Reproductive Medicine.)
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