期刊
FEBS LETTERS
卷 595, 期 18, 页码 2350-2365出版社
WILEY
DOI: 10.1002/1873-3468.14180
关键词
cancer; COVID-19; flux balance analysis; genome-scale metabolic modelling; multi-omics; SARS-CoV-2
资金
- Children's Liver Disease Foundation Research Grant
- UKRI Research England's THYME project
The study examined the interaction between COVID-19 and cancer, revealing metabolic alterations triggered by SARS-CoV-2 infection, as well as the impact on cellular biology and energy production pathways.
Cancer is considered a high-risk condition for severe illness resulting from COVID-19. The interaction between severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and human metabolism is key to elucidating the risk posed by COVID-19 for cancer patients and identifying effective treatments, yet it is largely uncharacterised on a mechanistic level. We present a genome-scale map of short-term metabolic alterations triggered by SARS-CoV-2 infection of cancer cells. Through transcriptomic- and proteomic-informed genome-scale metabolic modelling, we characterise the role of RNA and fatty acid biosynthesis in conjunction with a rewiring in energy production pathways and enhanced cytokine secretion. These findings link together complementary aspects of viral invasion of cancer cells, while providing mechanistic insights that can inform the development of treatment strategies.
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