期刊
FEBS JOURNAL
卷 289, 期 19, 页码 5834-5849出版社
WILEY
DOI: 10.1111/febs.16106
关键词
alcohol; basal ganglia; corticostriatal plasticity; dystonia; myoclonus; striatum
资金
- Italian Ministry of Health
- Italian Ministry of Health [EJP RD-135 2019]
- Cure Dystonia Now Foundation
- U.S. Department of Defense [PR191874]
- European Union's Horizon 2020 research and innovation program under the EJP RD COFUND-EJP [825575]
Alcohol consumption affects motor behavior and control, but the therapeutic mechanism for movement disorders like myoclonus-dystonia remains unclear, with few systematic trials on GABA drugs mimicking alcohol effects. This survey aims to summarize the impact of EtOH on striatal function and provide a mechanistic explanation for alcohol-responsive movement disorders, suggesting potential drug repositioning based on different hypotheses.
Alcohol consumption affects motor behavior and motor control. Both acute and chronic alcohol abuse have been extensively investigated; however, the therapeutic efficacy of alcohol on some movement disorders, such as myoclonus-dystonia or essential tremor, still does not have a plausible mechanistic explanation. Yet, there are surprisingly few systematic trials with known GABAergic drugs mimicking the effect of alcohol on neurotransmission. In this brief survey, we aim to summarize the effects of EtOH on striatal function, providing an overview of its cellular and synaptic actions in a 'circuit-centered' view. In addition, we will review both experimental and clinical evidence, in the attempt to provide a plausible mechanistic explanation for alcohol-responsive movement disorders, with particular emphasis on dystonia. Different hypotheses emerge, which may provide a rationale for the utilization of drugs that mimic alcohol effects, predicting potential drug repositioning.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据