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JOURNAL OF MEDICINAL CHEMISTRY (2020)
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Mcl-1 protects eosinophils from apoptosis and exacerbates allergic airway inflammation
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THORAX (2020)
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JOURNAL OF MEDICINAL CHEMISTRY (2020)
Mcl-1-mediated mitochondrial fission protects against stress but impairs cardiac adaptation to exercise
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JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2020)
Mcl-1 and Bok transmembrane domains: Unexpected players in the modulation of apoptosis
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)
MCL-1 gains occur with high frequency in lung adenocarcinoma and can be targeted therapeutically
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NATURE COMMUNICATIONS (2020)
Upregulation of Mcl-1S Causes Cell-Cycle Perturbations and DNA Damage Accumulation
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FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)
Pharmacological targeting of MCL-1 promotes mitophagy and improves disease pathologies in an Alzheimer's disease mouse model
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Discovery of S64315, a Potent and Selective Mcl-1 Inhibitor
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JOURNAL OF MEDICINAL CHEMISTRY (2020)
MCL1 binds and negatively regulates the transcriptional function of tumor suppressor p73
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CELL DEATH & DISEASE (2020)
Discovery and preclinical evaluation of AMG 397, a potent, selective and orally bioavailable MCL1 inhibitor
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Mcl-1 inhibition overcomes intrinsic and acquired regorafenib resistance in colorectal cancer
Xiangping Song et al.
THERANOSTICS (2020)
DNase II activated by the mitochondrial apoptotic pathway regulates RIP1-dependent non-apoptotic hepatocyte death via the TLR9/IFN-β signaling pathway
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CELL DEATH AND DIFFERENTIATION (2019)
LncRNA H19 overexpression induces bortezomib resistance in multiple myeloma by targeting MCL-1 via miR-29b-3p
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CELL DEATH & DISEASE (2019)
Circular RNA circHIPK3 promotes cell proliferation and invasion of prostate cancer by sponging miR-193a-3p and regulating MCL1 expression
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CANCER MANAGEMENT AND RESEARCH (2019)
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JOURNAL OF MEDICINAL CHEMISTRY (2019)
LncRNA ANRIL protects against oxygen and glucose deprivation (OGD)-induced injury in PC-12 cells: potential role in ischaemic stroke
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ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY (2019)
Establishing Drug Discovery and Identification of Hit Series for the Anti-apoptotic Proteins, Bcl-2 and Mcl-1
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ACS OMEGA (2019)
Long non-coding RNA MYOSLID functions as a competing endogenous RNA to regulate MCL-1 expression by sponging miR-29c-3p in gastric cancer
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CELL PROLIFERATION (2019)
BH3-only proteins target BCL-xL/MCL-1, not BAX/BAK, to initiate apoptosis
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CELL RESEARCH (2019)
Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Target Binding Ligands
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JOURNAL OF MEDICINAL CHEMISTRY (2019)
Mcl-1 Interacts with Akt to Promote Lung Cancer Progression
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CANCER RESEARCH (2019)
A Phase 1, First-in-Human Study of AMG 176, a Selective MCL-1 Inhibitor, in Patients With Relapsed or Refractory Multiple Myeloma
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CLINICAL LYMPHOMA MYELOMA & LEUKEMIA (2019)
Elevated expression of mcl-1 inhibits apoptosis and predicts poor prognosis in patients with surgically resected non-small cell lung cancer
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DIAGNOSTIC PATHOLOGY (2019)
Targeting melanoma's MCL1 bias unleashes the apoptotic potential of BRAF and ERK1/2 pathway inhibitors
Matthew J. Sale et al.
NATURE COMMUNICATIONS (2019)
Biomarker-driven strategy for MCL1 inhibition in T-cell lymphomas
Raphael Koch et al.
BLOOD (2019)
Mcl-1 and Bcl-xL are essential for survival of the developing nervous system
Lauren C. Fogarty et al.
CELL DEATH AND DIFFERENTIATION (2019)
LncRNA PMS2L2 protects ATDC5 chondrocytes against lipopolysaccharide-induced inflammatory injury by sponging miR-203
Xiaoyan Li et al.
LIFE SCIENCES (2019)
Targeting Mcl-1 inhibits survival and self-renewal of hepatocellular cancer stem-like cells
Huapeng Zhang et al.
CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY (2019)
Reducing Mcl-1 gene dosage induces dopaminergic neuronal loss and motor impairments in Park2 knockout mice
Susanna Ekholm-Reed et al.
COMMUNICATIONS BIOLOGY (2019)
Prediction of Hot Spots at Myeloid Cell Leukemia-1-Inhibitor Interface Using Energy Estimation and Alanine Scanning Mutagenesis
Parthiban Marimuthu et al.
BIOCHEMISTRY (2018)
Long noncoding RNA SNHG12 mediates doxorubicin resistance of osteosarcoma via miR-320a/MCL1 axis
Binghua Zhou et al.
BIOMEDICINE & PHARMACOTHERAPY (2018)
LINC00152 down-regulated miR-193a-3p to enhance MCL1 expression and promote gastric cancer cells proliferation
Yong Huang et al.
BIOSCIENCE REPORTS (2018)
Post-Transcriptional Regulation of Anti-Apoptotic BCL2 Family Members
Jia Cui et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)
Dynamic Regulation of Long-Chain Fatty Acid Oxidation by a Noncanonical Interaction between the MCL-1 BH3 Helix and VLCAD
Silvia Escudero et al.
MOLECULAR CELL (2018)
MCL-1 is a prognostic indicator and drug target in breast cancer
Kirsteen J. Campbell et al.
CELL DEATH & DISEASE (2018)
Long noncoding RNA LINC00152 promotes cell proliferation through competitively binding endogenous miR-125b with MCL-1 by regulating mitochondrial apoptosis pathways in ovarian cancer
Puxiang Chen et al.
CANCER MEDICINE (2018)
A Non-apoptotic Function of MCL-1 in Promoting Pluripotency and Modulating Mitochondrial Dynamics in Stem Cells
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STEM CELL REPORTS (2018)
Physiological Mitochondrial Fragmentation Is a Normal Cardiac Adaptation to Increased Energy Demand
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CIRCULATION RESEARCH (2018)
Role of Mcl-1 in regulation of cell death in human induced pluripotent stem cell-derived cardiomyocytes in vitro
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TOXICOLOGY AND APPLIED PHARMACOLOGY (2018)
A Novel MCL1 Inhibitor Combined with Venetoclax Rescues Venetoclax-Resistant Acute Myelogenous Leukemia
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CANCER DISCOVERY (2018)
AMG 176, a Selective MCL1 Inhibitor, Is Effective in Hematologic Cancer Models Alone and in Combination with Established Therapies
Sean Caenepeel et al.
CANCER DISCOVERY (2018)
Contribution of BH3-domain and Transmembrane-domain to the Activity and Interaction of the Pore-forming Bcl-2 Proteins Bok, Bak, and Bax
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SCIENTIFIC REPORTS (2018)
Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia
Adriana E. Tron et al.
NATURE COMMUNICATIONS (2018)
Humanized Mcl-1 mice enable accurate preclinical evaluation of MCL-1 inhibitors destined for clinical use
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BLOOD (2018)
Caspase cleavage of Mcl-1 impairs its anti-apoptotic activity and proteasomal degradation in non-small lung cancer cells
Ting Wang et al.
APOPTOSIS (2018)
Pro-Angiogenic Role of LncRNA HULC in Microvascular Endothelial Cells via Sequestrating miR-124
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CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2018)
Timed degradation of Mcl-1 controls mitotic cell death
Paul R. Clarke et al.
MOLECULAR & CELLULAR ONCOLOGY (2018)
Bax transmembrane domain interacts with prosurvival Bcl-2 proteins in biological membranes
Vicente Andreu-Fernandez et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)
Genetic neutrophil deficiency ameliorates cerebral ischemia-reperfusion injury
Ryan A. Frieler et al.
EXPERIMENTAL NEUROLOGY (2017)
Toward Understanding Mcl-1 Promiscuous and Specific Binding Mode
Jade Fogha et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2017)
The RNA-binding protein tristetraprolin schedules apoptosis of pathogen-engaged neutrophils during bacterial infection
Florian Ebner et al.
JOURNAL OF CLINICAL INVESTIGATION (2017)
Synergistic action of the MCL-1 inhibitor S63845 with current therapies in preclinical models of triple-negative and HER2-amplified breast cancer
Delphine Merino et al.
SCIENCE TRANSLATIONAL MEDICINE (2017)
The BCL-2 family of proteins and mitochondrial outer membrane permeabilisation
Richard W. Birkinshaw et al.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2017)
Quantitative interactome of a membrane Bcl-2 network identifies a hierarchy of complexes for apoptosis regulation
Stephanie Bleicken et al.
NATURE COMMUNICATIONS (2017)
MALAT1/miR-101-3p/MCL1 axis mediates cisplatin resistance in lung cancer
Huaqi Wang et al.
Oncotarget (2017)
Mcl-1 regulates reactive oxygen species via NOX4 during chemotherapy-induced senescence
Abeba Demelash et al.
ONCOTARGET (2017)
Voruciclib, a clinical stage oral CDK9 inhibitor, represses MCL-1 and sensitizes high-risk Diffuse Large B-cell Lymphoma to BCL2 inhibition
Joyoti Dey et al.
SCIENTIFIC REPORTS (2017)
A critical epithelial survival axis regulated by MCL-1 maintains thymic function in mice
Reema Jain et al.
BLOOD (2017)
Norcantharidin induces mitochondrial-dependent apoptosis through Mcl-1 inhibition in human prostate cancer cells
Chu-Liang Lin et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2017)
MCL-1 Is a Key Antiapoptotic Protein in Human and Rodent Pancreatic β-Cells
Kira Meyerovich et al.
DIABETES (2017)
Mcl-1 Degradation Is Required for Targeted Therapeutics to Eradicate Colon Cancer Cells
Jingshan Tong et al.
CANCER RESEARCH (2017)
Deactivation of Mcl-1 by Dual-Function Small-Molecule Inhibitors Targeting the Bcl-2 Homology 3 Domain and Facilitating Mcl-1 Ubiquitination
Ting Song et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2016)
MicroRNA-30 inhibits antiapoptotic factor Mcl-1 in mouse and human hematopoietic cells after radiation exposure
Xiang Hong Li et al.
APOPTOSIS (2016)
PTBP1 modulation of MCL1 expression regulates cellular apoptosis induced by antitubulin chemotherapeutics
J. Cui et al.
CELL DEATH AND DIFFERENTIATION (2016)
The lncRNA MALAT1 functions as a competing endogenous RNA to regulate MCL-1 expression by sponging miR-363-3p in gallbladder cancer
Shou-Hua Wang et al.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2016)
Mcl-1 involvement in mitochondrial dynamics is associated with apoptotic cell death
Giampaolo Morciano et al.
MOLECULAR BIOLOGY OF THE CELL (2016)
The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models
Andras Kotschy et al.
NATURE (2016)
Down-regulation of miR-320 associated with cancer progression and cell apoptosis via targeting Mcl-1 in cervical cancer
Ting Zhang et al.
TUMOR BIOLOGY (2016)
Loss of a Single Mcl-1 Allele Inhibits MYC-Driven Lymphomagenesis by Sensitizing Pro-B Cells to Apoptosis
Stephanie Grabow et al.
CELL REPORTS (2016)
Activation of the Mitochondrial Apoptotic Pathway Produces Reactive Oxygen Species and Oxidative Damagein Hepatocytes That Contribute to Liver Tumorigenesis
Hayato Hikita et al.
CANCER PREVENTION RESEARCH (2015)
Myeloid cell leukemia-1 is an important apoptotic survival factor in triple-negative breast cancer
C. M. Goodwin et al.
CELL DEATH AND DIFFERENTIATION (2015)
Structure-Function Analysis of the Mcl-1 Protein Identifies a Novel Senescence-regulating Domain
Abeba Demelash et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2015)
In non-transformed cells Bak activates upon loss of anti-apoptotic Bcl-XL and Mcl-1 but in the absence of active BH3-only proteins
D. Senft et al.
CELL DEATH & DISEASE (2015)
MicroRNA-101 inhibits cell progression and increases paclitaxel sensitivity by suppressing MCL-1 expression in human triple-negative breast cancer
Xiaoping Liu et al.
ONCOTARGET (2015)
A kinase inhibitor screen identifies Mcl-1 and Aurora kinase A as novel treatment targets in antiestrogen-resistant breast cancer cells
S. Thrane et al.
ONCOGENE (2015)
Inhibition of FGFR signaling by PD173074 improves antitumor immunity and impairs breast cancer metastasis
Tinghong Ye et al.
BREAST CANCER RESEARCH AND TREATMENT (2014)
Targeting of MCL-1 kills MYC-driven mouse and human lymphomas even when they bear mutations in p53
Gemma L. Kelly et al.
GENES & DEVELOPMENT (2014)
RNA-dependent dynamic histone acetylation regulates MCL1 alternative splicing
Dilshad H. Khan et al.
NUCLEIC ACIDS RESEARCH (2014)
High-Quality NMR Structure of Human Anti-Apoptotic Protein Domain Mcl-1(171-327) for Cancer Drug Design
Gaohua Liu et al.
PLOS ONE (2014)
Estrogen Regulation of Anti-Apoptotic Bcl-2 Family Member Mcl-1 Expression in Breast Cancer Cells
Jennifer L. Schacter et al.
PLOS ONE (2014)
Prosurvival Bcl-2 family members affect autophagy only indirectly, by inhibiting Bax and Bak
Lisa M. Lindqvist et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Multiple components of the spliceosome regulate Mcl1 activity in neuroblastoma
T. W. Laetsch et al.
CELL DEATH & DISEASE (2014)
Mcl-1 promotes lung cancer cell migration by directly interacting with VDAC to increase mitochondrial Ca2+ uptake and reactive oxygen species generation
H. Huang et al.
CELL DEATH & DISEASE (2014)
Beclin 1 restrains tumorigenesis through Mcl-1 destabilization in an autophagy-independent reciprocal manner
Mohamed Elgendy et al.
NATURE COMMUNICATIONS (2014)
HTLV-1 Tax Stabilizes MCL-1 via TRAF6-Dependent K63-Linked Polyubiquitination to Promote Cell Survival and Transformation
Young Bong Choi et al.
PLOS PATHOGENS (2014)
Ionizing radiation-inducible microRNA miR-193a-3p induces apoptosis by directly targeting Mcl-1
Jeong-Eun Kwon et al.
APOPTOSIS (2013)
Placental autophagy regulation by the BOK-MCL1 rheostat
Manpreet Kalkat et al.
AUTOPHAGY (2013)
MicroRNA-133a, downregulated in osteosarcoma, suppresses proliferation and promotes apoptosis by targeting Bcl-xL and Mcl-1
Fang Ji et al.
BONE (2013)
Polymeric delivery of siRNA for dual silencing of Mel-1 and P-glycoprotein and apoptosis induction in drug-resistant breast cancer cells
H. M. Aliabadi et al.
CANCER GENE THERAPY (2013)
The C-terminal helix of BcI-xL mediates Bax retrotranslocation from the mitochondria
F. Todt et al.
CELL DEATH AND DIFFERENTIATION (2013)
Mcl1 regulates the terminal mitosis of neural precursor cells in the mammalian brain through p27Kip1
S. M. Mahmudul Hasan et al.
DEVELOPMENT (2013)
Loss of MCL-1 leads to impaired autophagy and rapid development of heart failure
Robert L. Thomas et al.
GENES & DEVELOPMENT (2013)
Deletion of MCL-1 causes lethal cardiac failure and mitochondrial dysfunction
Xi Wang et al.
GENES & DEVELOPMENT (2013)
The Bcl-2 Homology Domain 3 (BH3)-only Proteins Bim and Bid Are Functionally Active and Restrained by Anti-apoptotic Bcl-2 Family Proteins in Healthy Liver
Takahiro Kodama et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
Discovery of Potent Myeloid Cell Leukemia 1 (Mcl-1) Inhibitors Using Fragment-Based Methods and Structure-Based Design
Anders Friberg et al.
JOURNAL OF MEDICINAL CHEMISTRY (2013)
Targeting FLIP and Mcl-1 using a combination of aspirin and sorafenib sensitizes colon cancer cells to TRAIL
Bodvael Pennarun et al.
JOURNAL OF PATHOLOGY (2013)
Mcl-1 is essential for the survival of plasma cells
Victor Peperzak et al.
NATURE IMMUNOLOGY (2013)
MicroRNA-125b promotes apoptosis by regulating the expression of Mcl-1, Bcl-w and IL-6R
J. Gong et al.
ONCOGENE (2013)
MCL-1ES Induces MCL-1L-Dependent BAX- and BAK-Independent Mitochondrial Apoptosis
Jae-Hong Kim et al.
PLOS ONE (2013)
VDAC1 selectively transfers apoptotic Ca2+ signals to mitochondria
D. De Stefani et al.
CELL DEATH AND DIFFERENTIATION (2012)
Mcl-1 and Bcl-xL regulate Bak/Bax-dependent apoptosis of the megakaryocytic lineage at multistages
T. Kodama et al.
CELL DEATH AND DIFFERENTIATION (2012)
Anti-apoptotic Mcl-1 is essential for the development and sustained growth of acute myeloid leukemia
Stefan P. Glaser et al.
GENES & DEVELOPMENT (2012)
Bak deficiency inhibits liver carcinogenesis: A causal link between apoptosis and carcinogenesis
Hayato Hikita et al.
JOURNAL OF HEPATOLOGY (2012)
Inhibition of Mcl-1 Promotes Senescence in Cancer Cells: Implications for Preventing Tumor Growth and Chemotherapy Resistance
Elzbieta Bolesta et al.
MOLECULAR AND CELLULAR BIOLOGY (2012)
Anti-apoptotic MCL-1 localizes to the mitochondrial matrix and couples mitochondrial fusion to respiration
Rhonda M. Perciavalle et al.
NATURE CELL BIOLOGY (2012)
Predominant requirement of Bax for apoptosis in HCT116 cells is determined by Mcl-1's inhibitory effect on Bak
C. Wang et al.
ONCOGENE (2012)
Regulation of Mcl-1 by SRSF1 and SRSF5 in Cancer Cells
Hannah L. Gautrey et al.
PLOS ONE (2012)
Mitochondrial Fission, Fusion, and Stress
Richard J. Youle et al.
SCIENCE (2012)
Noxa controls Mule-dependent Mcl-1 ubiquitination through the regulation of the Mcl-1/USP9X interaction
Patricia Gomez-Bougie et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2011)
Evidence that inhibition of BAX activation by BCL-2 involves its tight and preferential interaction with the BH3 domain of BAX
Bonsu Ku et al.
CELL RESEARCH (2011)
MCL-1 is a stress sensor that regulates autophagy in a developmentally regulated manner
Marc Germain et al.
EMBO JOURNAL (2011)
Probing the difference between BH3 groove of Mcl-1 and Bcl-2 protein: Implications for dual inhibitors design
Zhichao Zhang et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2011)
The RNA-Binding Protein HuR Promotes Glioma Growth and Treatment Resistance
Natalia Filippova et al.
MOLECULAR CANCER RESEARCH (2011)
Epidermal growth factor regulates Mcl-1 expression through the MAPK-Elk-1 signalling pathway contributing to cell survival in breast cancer
E. P. Booy et al.
ONCOGENE (2011)
Mitochondria Supply Membranes for Autophagosome Biogenesis during Starvation
Dale W. Hailey et al.
CELL (2010)
MCL-1 localizes to sites of DNA damage and regulates DNA damage response
Sarwat Jamil et al.
CELL CYCLE (2010)
ATM-dependent expression of IEX-1 controls nuclear accumulation of Mcl-1 and the DNA damage response
P. Pawlikowska et al.
CELL DEATH AND DIFFERENTIATION (2010)
ERBB2 Induces an Antiapoptotic Expression Pattern of Bcl-2 Family Members in Node-Negative Breast Cancer
Ilka Brigitte Petry et al.
CLINICAL CANCER RESEARCH (2010)
Phosphorylation of Mcl-1 by CDK1-cyclin B1 initiates its Cdc20-dependent destruction during mitotic arrest
Margaret E. Harley et al.
EMBO JOURNAL (2010)
The fast-mobility isoform of mouse Mcl-1 is a mitochondrial matrix-localized protein with attenuated anti-apoptotic activity
Chi-Ruei Huang et al.
FEBS LETTERS (2010)
Mcl-1; the molecular regulation of protein function
Luke W. Thomas et al.
FEBS LETTERS (2010)
Hepatocyte-Specific Deletion of the Antiapoptotic Protein Myeloid Cell Leukemia-1 Triggers Proliferation and Hepatocarcinogenesis in Mice
Achim Weber et al.
HEPATOLOGY (2010)
The Bcl-xL Inhibitor, ABT-737, Efficiently Induces Apoptosis and Suppresses Growth of Hepatoma Cells in Combination with Sorafenib
Hayato Hikita et al.
HEPATOLOGY (2010)
Downregulations of B-cell lymphoma 2 and myeloid cell leukemia sequence 1 by microRNA 153 induce apoptosis in a glioblastoma cell line DBTRG-05MG
Jianzhen Xu et al.
INTERNATIONAL JOURNAL OF CANCER (2010)
Apoptosis Protection by Mcl-1 and Bcl-2 Modulation of Inositol 1,4,5-Trisphosphate Receptor-dependent Ca2+ Signaling
Emily F. Eckenrode et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Ubiquitin-Independent Degradation of Antiapoptotic MCL-1
Daniel P. Stewart et al.
MOLECULAR AND CELLULAR BIOLOGY (2010)
Lyn Kinase-Dependent Regulation of miR181 and Myeloid Cell Leukemia-1 Expression: Implications for Drug Resistance in Myelogenous Leukemia
Eric I. Zimmerman et al.
MOLECULAR PHARMACOLOGY (2010)
The landscape of somatic copy-number alteration across human cancers
Rameen Beroukhim et al.
NATURE (2010)
Glycolysis inhibition sensitizes tumor cells to death receptors-induced apoptosis by AMP kinase activation leading to Mcl-1 block in translation
L. A. Pradelli et al.
ONCOGENE (2010)
Mcl-1 Is Essential for Germinal Center Formation and B Cell Memory
Ingela Vikstrom et al.
SCIENCE (2010)
MicroRNA 133B targets pro-survival molecules MCL-1 and BCL2L2 in lung cancer
Melissa Crawford et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2009)
Selective roles for antiapoptotic MCL-1 during granulocyte development and macrophage effector function
Desiree A. Steimer et al.
BLOOD (2009)
MCL-1ES, a novel variant of MCL-1, associates with MCL-1L and induces mitochondrial cell death
Jae-Hong Kim et al.
FEBS LETTERS (2009)
Knockout of Myeloid Cell Leukemia-1 Induces Liver Damage and Increases Apoptosis Susceptibility of Murine Hepatocytes
Binje Vick et al.
HEPATOLOGY (2009)
Mcl-1 and Bcl-xL Cooperatively Maintain Integrity of Hepatocytes in Developing and Adult Murine Liver
Hayato Hikita et al.
HEPATOLOGY (2009)
Prognostic Role of Myeloid Cell Leukemia-1 Protein (Mcl-1) Expression in Human Gastric Cancer
Wang Likui et al.
JOURNAL OF SURGICAL ONCOLOGY (2009)
Chromatin remodeling at Alu repeats by epigenetic treatment activates silenced microRNA-512-5p with downregulation of Mcl-1 in human gastric cancer cells
Y. Saito et al.
ONCOGENE (2009)
Translation inhibition during cell cycle arrest and apoptosis: Mcl-1 is a novel target for RNA binding protein CUGBP2
Dharmalingam Subramaniam et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2008)
Differential regulation of Bax and Bak by anti-apoptotic Bcl-2 family proteins Bcl-B and Mcl-1
Dayong Zhai et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum
Elizabeth L. Axe et al.
JOURNAL OF CELL BIOLOGY (2008)
Structure of the BH3 domains from the p53-inducible BH3-only proteins Noxa and Puma in complex with Mcl-1
Catherine L. Day et al.
JOURNAL OF MOLECULAR BIOLOGY (2008)
Down-regulation of Mcl-1 by small interfering RNA sensitizes resistant melanoma cells to Fas-mediated apoptosis
Nizar Chetoui et al.
MOLECULAR CANCER RESEARCH (2008)
mTORC1 promotes survival through translational control of Mcl-1
John R. Mills et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Hydrophile scanning as a complement to alanine scanning for exploring and manipulating protein-protein recognition: Application to the Bim BH3 domain
Melissa D. Boersma et al.
PROTEIN SCIENCE (2008)
The N terminus of the anti-apoptotic BCL-2 homologue MCL-1 regulates its localization and function
Marc Germain et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Differential interactions between Beclin 1 and bcl-2 family members
Shlomit Erlich et al.
AUTOPHAGY (2007)
mir-29 regulates Mcl-1 protein expression and apoptosis
J. L. Mott et al.
ONCOGENE (2007)
Therapeutic window for melanoma treatment provided by selective effects of the proteasome on Bcl-2 proteins
K. G. Wolter et al.
CELL DEATH AND DIFFERENTIATION (2007)
Translational repression of MCL-1 couples stress-induced eIF2α phosphorylation to mitochondrial apoptosis initiation
Ralph M. Fritsch et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Serine 64 phosphorylation enhances the antiapoptotic function of Mcl-1
Shogo Kobayashi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Degradation of Mcl-1 by β-TrCP mediates glycogen synthase kinase 3-induced tumor suppression and chemosensitization
Qingqing Ding et al.
MOLECULAR AND CELLULAR BIOLOGY (2007)
Myeloid cell leukemia-1 inversely correlates with glycogen synthase kinase-3β activity and associates with poor prognosis in human breast cancer
Qingqing Ding et al.
CANCER RESEARCH (2007)
Structural insights into the degradation of Mcl-1 induced by BH3 domains
Peter E. Czabotar et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
The antiapoptotic protein Mcl-1 is essential for the survival of neutrophils but not macrophages
Ivan Dzhagalov et al.
BLOOD (2007)
Mechanism and functional role of XIAP and McI-1 down-regulation in flavopiridol/vorinostat antileukemic interactions
Roberto R. Rosato et al.
MOLECULAR CANCER THERAPEUTICS (2007)
Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia
Marina Konopleva et al.
CANCER CELL (2006)
20S proteasomes and protein degradation by default
Gad Asher et al.
BIOESSAYS (2006)
Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members
Michael Certo et al.
CANCER CELL (2006)
Herceptin sensitizes ErbB2 - Overexpressing cells to apoptosis by reducing antiapoptotic Mcl-1 expression
ES Henson et al.
CLINICAL CANCER RESEARCH (2006)
Mcl-1 overexpression in hepatocellular carcinoma: A potential target for antisense therapy
W Sieghart et al.
JOURNAL OF HEPATOLOGY (2006)
Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis
Q Zhong et al.
CELL (2005)
Mcl-1 is overexpressed in multiple myeloma and associated with relapse and shorter survival
S Wuillème-Toumi et al.
LEUKEMIA (2005)
Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins
SN Willis et al.
GENES & DEVELOPMENT (2005)
A proteolytic fragment of Mcl-1 exhibits nuclear localization and regulates cell growth by interaction with Cdk1
S Jamil et al.
BIOCHEMICAL JOURNAL (2005)
Disruption of Mcl-1•Bim complex in granzyme B-mediated mitochondrial apoptosis
J Han et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Stabilization and enhancement of the antiapoptotic activity of Mcl-1 by TCTP
H Liu et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
Obligate role of anti-apoptotic MCL-1 in the survival of hematopoietic stem cells
JT Opferman et al.
SCIENCE (2005)
Solution structure of prosurvival Mcl-1 and characterization of its binding by proapoptotic BH3-only ligands
CL Day et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Structural biology of the Bcl-2 family of proteins
AM Petros et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2004)
Characterisation of Mcl-1 cleavage during apoptosis of haematopoietic cells
JG Clohessy et al.
BRITISH JOURNAL OF HAEMATOLOGY (2004)
Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1
JT Opferman et al.
NATURE (2003)
Solution structure of human BCL-w - Modulation of ligand binding by the C-terminal helix
AY Denisov et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Mcl-1 antisense therapy chemosensitizes human melanoma in a SCID mouse xenotransplantation model
C Thallinger et al.
JOURNAL OF INVESTIGATIVE DERMATOLOGY (2003)
Increased MCL-1 expression is associated with poor prognosis in ovarian carcinomas
K Shigemasa et al.
JAPANESE JOURNAL OF CANCER RESEARCH (2002)
Direct repression of the Mcl-1 promoter by E2F1
R Croxton et al.
ONCOGENE (2002)
MCL1 transgenic mice exhibit a high incidence of B-cell lymphoma manifested as a spectrum of histologic subtypes
P Zhou et al.
BLOOD (2001)
Rb, mcl-1 and p53 expression correlate with clinical outcome in patients with liver metastases from colorectal cancer
HHJ Backus et al.
ANNALS OF ONCOLOGY (2001)
Regulation of apoptosis and cell cycle progression by MCL1 - Differential role of proliferating cell nuclear antigen
K Fujise et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Structure of Bax: Coregulation of dimer formation and intracellular localization
M Suzuki et al.
CELL (2000)
MCL-1S, a splicing variant of the antiapoptotic BCL-2 family member MCL-1, encodes a proapoptotic protein possessing only the BH3 domain
J Bae et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Exon skipping in Mcl-1 results in a Bcl-2 homology domain 3 only gene product that promotes cell death
CD Bingle et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Functional analysis of the human MCL-1 gene
C Akgul et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2000)
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