期刊
FEBS JOURNAL
卷 289, 期 24, 页码 8032-8036出版社
WILEY
DOI: 10.1111/febs.16207
关键词
cytokine; IL-10; immunology; inflammation; JAK; protein engineering; receptor; signaling; STAT
资金
- NIH [NIH R37-AI51321]
IL-10 is an immunomodulatory cytokine with important roles in terminating inflammatory responses and preventing tissue damage from autoimmunity. However, its pleiotropic nature and ability to elicit proinflammatory effects in vivo have hindered therapeutic efforts utilizing IL-10.
Interleukin-10 (IL-10) is an immunomodulatory cytokine that plays important roles in terminating inflammatory responses and preventing tissue damage resulting from autoimmunity. Although these anti-inflammatory actions have led to considerable clinical interest, efforts to exploit IL-10 therapeutically have been hindered by the highly pleiotropic nature of IL-10 and its ability to elicit proinflammatory effects in vivo. In this structural snapshot, we review the recent cryo-EM structure of the IL-10 receptor signaling complex, highlighting its unique structural features, insights into the mechanism of receptor sharing by the IL-10 cytokine family, and the implications for manipulating IL-10 signaling therapeutically.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据