4.6 Editorial Material

Cryo-EM structure of the IL-10 receptor complex provides a blueprint for ligand engineering

期刊

FEBS JOURNAL
卷 289, 期 24, 页码 8032-8036

出版社

WILEY
DOI: 10.1111/febs.16207

关键词

cytokine; IL-10; immunology; inflammation; JAK; protein engineering; receptor; signaling; STAT

资金

  1. NIH [NIH R37-AI51321]

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IL-10 is an immunomodulatory cytokine with important roles in terminating inflammatory responses and preventing tissue damage from autoimmunity. However, its pleiotropic nature and ability to elicit proinflammatory effects in vivo have hindered therapeutic efforts utilizing IL-10.
Interleukin-10 (IL-10) is an immunomodulatory cytokine that plays important roles in terminating inflammatory responses and preventing tissue damage resulting from autoimmunity. Although these anti-inflammatory actions have led to considerable clinical interest, efforts to exploit IL-10 therapeutically have been hindered by the highly pleiotropic nature of IL-10 and its ability to elicit proinflammatory effects in vivo. In this structural snapshot, we review the recent cryo-EM structure of the IL-10 receptor signaling complex, highlighting its unique structural features, insights into the mechanism of receptor sharing by the IL-10 cytokine family, and the implications for manipulating IL-10 signaling therapeutically.

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