AgRP neurons: Regulators of feeding, energy expenditure, and behavior

Neurons in the hypothalamic arcuate nucleus (ARC) that express agouti-related peptide (AgRP) govern a critical aspect of survival: the drive to eat. Equally important to survival is the timing at which food is consumed-seeking or eating food to alleviate hunger in the face of a more pressing threat, like the risk of predation, is clearly maladaptive. To ensure optimal prioritization of behaviors within a given environment, therefore, AgRP neurons must integrate signals of internal need states with contextual environmental cues. In this state-of-the-art review, we highlight recent advances that extend our understanding of AgRP neurons, including the neural circuits they engage to regulate feeding, energy expenditure, and behavior. We also discuss key findings that illustrate how both classical feedback and anticipatory feedforward signals regulate this neuronal population and how the integration of these signals may be disrupted in states of energy excess. Finally, we examine both technical and conceptual challenges facing the field moving forward.

Automated summary

This review discusses the regulation of feeding drive and timing by AgRP neurons in the hypothalamic arcuate nucleus, as well as their integration with environmental cues to ensure optimal prioritization of behaviors. It also explores how classical feedback and anticipatory feedforward signals regulate these neurons, and examines how the integration of these signals may be disrupted in states of energy excess.