期刊
FASEB JOURNAL
卷 35, 期 6, 页码 -出版社
WILEY
DOI: 10.1096/fj.202100242R
关键词
adipose tissue; extracellular vesicles; lipolysis; microRNAs; skeletal muscle
资金
- National Institute of Diabetes and Digestive and Kidney Diseases [R01DK119619]
- Futurum-the Academy for Health and Care, Region Jonkoping County
- Swedish Research Council for Sports Science
Regular physical activity may improve health by releasing factors from skeletal muscle through extracellular vesicles (EVs) containing miR-1, promoting adipose tissue metabolic adaptations. EVs are preferentially taken up by eWAT, enhancing adrenergic signaling and lipolysis, ultimately benefiting overall health.
How regular physical activity is able to improve health remains poorly understood. The release of factors from skeletal muscle following exercise has been proposed as a possible mechanism mediating such systemic benefits. We describe a mechanism wherein skeletal muscle, in response to a hypertrophic stimulus induced by mechanical overload (MOV), released extracellular vesicles (EVs) containing muscle-specific miR-1 that were preferentially taken up by epidydimal white adipose tissue (eWAT). In eWAT, miR-1 promoted adrenergic signaling and lipolysis by targeting Tfap2 alpha, a known repressor of Adr beta 3 expression. Inhibiting EV release prevented the MOV-induced increase in eWAT miR-1 abundance and expression of lipolytic genes. Resistance exercise decreased skeletal muscle miR-1 expression with a concomitant increase in plasma EV miR-1 abundance, suggesting a similar mechanism may be operative in humans. Altogether, these findings demonstrate that skeletal muscle promotes metabolic adaptations in adipose tissue in response to MOV via EV-mediated delivery of miR-1.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据