4.7 Article

Maternal whole grain intake and outcomes of in vitro fertilization

期刊

FERTILITY AND STERILITY
卷 105, 期 6, 页码 1503-U170

出版社

ELSEVIER SCIENCE INC
DOI: 10.1016/j.fertnstert.2016.02.015

关键词

Whole grains; in vitro fertilization; female infertility; assisted reproductive technology

资金

  1. National Institutes of Health from National Institute of Environmental Health Sciences [R01-ES009718]
  2. National Institutes of Health from National Institute of Diabetes and Digestive and Kidney Diseases [P30-DK046200, T32-DK007703-16]
  3. National Institutes of Health from National Institute of Child Health and Human Development [L50-HD085359]

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Objective: To evaluate the relationship between pretreatment intake of whole grains and outcomes of IVF. Design: Prospective cohort study. Setting: Academic medical center. Patient(s): A total of 273 women who collectively underwent 438 IVF cycles. Intervention(s): Whole grain intake was assessed with a validated food frequency questionnaire at enrollment. Main Outcome Measure(s): Intermediate and clinical end points of IVF were abstracted from medical records. Result(s): Women had a median whole grain intake of 34.2 g per day (similar to 1.2 servings/day). Higher pretreatment whole grain intake was associated with higher probability of implantation and live birth. The adjusted percentage of cycles resulting in live birth for women in the highest quartile of whole grain intake (>52.4 g/day) was 53% (95% confidence interval [CI] 41%, 65%) compared with 35% (95% CI 25%, 46%) for women in the lowest quartile (<21.4 g/day). This association was largely driven by intake of bran as opposed to germ. When intermediate end points of IVF were examined, only endometrial thickness on the day of ET was associated with whole grain intake. A 28-g per day (similar to 1 serving/day) increase in whole grain intake was associated with a 0.4-mm (95% CI 0.1, 0.7 mm) increase in endometrial thickness. Conclusion(s): Higher pretreatment whole grain intake was related to higher probability of live birth among women undergoing IVF. The higher probability of live birth may result from increased endometrial thickness on the day of ET and improved embryo receptivity manifested in a higher probability of implantation. (C) 2016 by American Society for Reproductive Medicine.)

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