☆ 4.4 Review

COVID-19 pandemic: SARS-CoV-2 specific vaccines and challenges, protection via BCG trained immunity, and clinical trials

EXPERT REVIEW OF VACCINES (2021)

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Review Immunology

Tuberculosis vaccine BCG: the magical effect of the old vaccine in the fight against the COVID-19 pandemic

Ashok Aspatwar et al.

Summary: BCG vaccine plays a key role in reducing childhood mortality rates, protecting children against respiratory infections, lowering the risk of malaria, and providing immunity against respiratory infections in elderly people. Additionally, BCG also offers nonspecific innate immunity and has the potential to act as a protective agent against COVID-19.

INTERNATIONAL REVIEWS OF IMMUNOLOGY (2022)

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Editorial Material Medicine, Research & Experimental

BCG vaccination in health care providers and the protection against COVID-19

Mihai G. Netea et al.

Summary: Several COVID-19 vaccine candidates have shown promise, but uncertainty remains about their effectiveness and global distribution. Boosting innate immunity with vaccines like BCG may play a role in combating COVID-19, as evidenced by lower infection and seropositivity rates in BCG-vaccinated individuals. Further clinical trials are needed to explore the potential of BCG vaccination in COVID-19 and future pandemics.

JOURNAL OF CLINICAL INVESTIGATION (2021)

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Review Virology

Hidden in plain sight: The effects of BCG vaccination in the COVID-19 pandemic

Eman A. Toraih et al.

Summary: The study investigated the potential protective role of BCG vaccination against COVID-19 by analyzing gene expression pathways using a bioinformatics approach. Results showed an overlap in immune and inflammatory pathways between the BCG-vaccinated group and the SARS-CoV-2 infection group, suggesting a possible mechanism for the protective effect of BCG vaccination against COVID-19.

JOURNAL OF MEDICAL VIROLOGY (2021)

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News Item Multidisciplinary Sciences

COULD NEW COVID VARIANTS UNDERMINE VACCINES? LABS SCRAMBLE TO FIND OUT

Ewen Callaway

NATURE (2021)

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Article Mathematics, Applied

Complexity analysis of cold chain transportation in a vaccine supply chain considering activity inspection and time-delay

Daoming Dai et al.

Summary: The paper focuses on vaccine transportation in a COVID-19 supply chain model, examining the roles of distributor and retailer and how their decisions impact system stability. Results indicate that decision delay-time and adjustment speed significantly affect supply chain stability, with the stability domain of the system changing with customers' sensitivity to cold chain transportation and vaccine prices.

ADVANCES IN DIFFERENCE EQUATIONS (2021)

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Article Public, Environmental & Occupational Health

Emergence of SARS-CoV-2 B.1.1.7 Lineage — United States, December 29, 2020–January 12, 2021

Summer E. Galloway et al.

MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT (2021)

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Article Public, Environmental & Occupational Health

The Advisory Committee on Immunization Practices' Interim Recommendation for Use of Moderna COVID-19 Vaccine - United States, December 2020

Sara E. Oliver et al.

MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT (2021)

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Article Public, Environmental & Occupational Health

COVID-19 vaccine acceptance among pregnant women and mothers of young children: results of a survey in 16 countries

Malia Skjefte et al.

Summary: The study found that COVID-19 vaccine acceptance among pregnant women and mothers of young children varied globally, with higher acceptance rates in India, the Philippines, and Latin American countries, and lower rates in Russia, the United States, and Australia. The main predictors of vaccine acceptance included confidence in vaccine safety and effectiveness, concern about COVID-19, trust in public health agencies, adherence to mask guidelines, and attitudes towards routine vaccines.

EUROPEAN JOURNAL OF EPIDEMIOLOGY (2021)

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Article Medicine, General & Internal

Immunogenicity of the Ad26.COV2.S Vaccine for COVID-19

Kathryn E. Stephenson et al.

Summary: The study evaluated the immunogenicity of the Ad26.COV2.S vaccine in human participants, showing rapid induction of spike-specific humoral and cellular immune responses. Various antibody subclasses, Fc receptor binding properties, and antiviral functions were induced, along with CD4+ and CD8+ T-cell responses.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

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Letter Public, Environmental & Occupational Health

Building public trust in COVID-19 vaccines through the Catholic Church in the Philippines

Jose Ma W. Gopez

Summary: The hesitation of many Filipinos towards the government's inoculation program due to expedited vaccine production has highlighted the importance of gaining public trust. This paper suggests that the Catholic Church, as an influential institution in the Philippines, can play a key role in building trust in COVID-19 vaccines in the country.

JOURNAL OF PUBLIC HEALTH (2021)

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Article Medicine, General & Internal

Single-dose administration and the influence of the timing of the booster dose on immunogenicity and efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine: a pooled analysis of four randomised trials

Merryn Voysey et al.

Summary: The AZD1222 vaccine has been approved for emergency use in the UK with an interval of 4-12 weeks between doses. Analysis shows that the vaccine is efficacious with two doses and provides immunoprotection after the first dose before the second dose is administered.

LANCET (2021)

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Editorial Material Medicine, General & Internal

Urgent needs of low-income and middle-income countries for COVID-19 vaccines and therapeutics

J. Peter Figueroa et al.

LANCET (2021)

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Editorial Material Medicine, General & Internal

Sputnik V COVID-19 vaccine candidate appears safe and effective Comment

Ian Jones et al.

LANCET (2021)

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Article Multidisciplinary Sciences

mRNA vaccine-elicited antibodies to SARS-CoV-2 and circulating variants

Zijun Wang et al.

Summary: Volunteers who received the Moderna or Pfizer-BioNTech vaccine showed high levels of antibodies and memory B cell responses against SARS-CoV-2, with activity similar to individuals who had recovered from natural infection. However, their efficacy against specific SARS-CoV-2 variants was reduced, indicating a potential need for periodic updates to mRNA vaccines to maintain clinical efficacy.

NATURE (2021)

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Article Immunology

The potential effects of deploying SARS-Cov-2 vaccines on cold storage capacity and immunization workload in countries of the WHO African Region

Justin R. Ortiz et al.

Summary: In the African region, SARS-CoV-2 vaccination campaigns will significantly increase doses per vaccinator and cold storage capacity requirements, requiring immediate strengthening of immunization systems to support pandemic responses.

VACCINE (2021)

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Article Immunology

Two Different Antibody-Dependent Enhancement (ADE) Risks for SARS-CoV-2 Antibodies

Darrell O. Ricke

Summary: The severity and stages of COVID-19 vary, with different pathological processes such as cytokine storms, ARDS, etc., and the development of related vaccines is hindered by vaccine-induced enhanced disease responses.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Virology

Pervasive transmission of E484K and emergence of VUI-NP13L with evidence of SARS-CoV-2 co-infection events by two different lineages in Rio Grande do Sul, Brazil

Ronaldo da Silva Francisco Jr et al.

Summary: The emergence of novel SARS-CoV-2 lineages, including B.1.1.28 (E484K), in Rio Grande do Sul, Brazil has raised global concerns. Co-infection events and the identification of a new sample cluster named VUI-NP13L underscore the importance of strict and effective social distancing measures to combat the spread of potentially more hazardous SARS-CoV-2 strains.

VIRUS RESEARCH (2021)

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Article Immunology

Peptides-Based Vaccine MP3RT Induced Protective Immunity Against Mycobacterium Tuberculosis Infection in a Humanized Mouse Model

Wenping Gong et al.

Summary: The study developed a novel tuberculosis vaccine MP3RT based on peptides, which showed promising protective efficacy in humanized mice by significantly reducing pathogen load and inflammatory cell count, as well as inducing high levels of IFN-γ and CD3(+)IFN-γ(+) T lymphocytes. These findings provide a foundation for the development of peptide-based vaccines against TB.

FRONTIERS IN IMMUNOLOGY (2021)

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Letter Immunology

Genomic Evidence of SARS-CoV-2 Reinfection Involving E484K Spike Mutation, Brazil

Carolina Kymie Vasques Nonaka et al.

Summary: The case of reinfection from distinct virus lineages in Brazil with the E484K mutation raises concerns about the duration of protective immune responses against SARS-CoV-2, especially with the variant associated with escape from neutralizing antibodies. This highlights potential challenges for virus control measures.

EMERGING INFECTIOUS DISEASES (2021)

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Article Medicine, General & Internal

Geospatial Analysis of Age-specific SARS-CoV-2 Transmission Patterns in Households, Korea

Seonju Yi et al.

Summary: The study found that within-age group infection dominated household transmissions of COVID-19 in Korea, and transmission of SARS-CoV-2 was more common from adults to children than from children to adults.

JOURNAL OF KOREAN MEDICAL SCIENCE (2021)

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Review Geriatrics & Gerontology

Review of COVID-19 Vaccines and Their Evidence in Older Adults

Shyh Poh Teo

Summary: The COVID-19 pandemic has had a significant impact on older adults, making them a priority group for vaccination. Different types of COVID-19 vaccines have shown varying effectiveness in older adults, with some vaccines demonstrating high efficacy and immunogenicity in this population. However, further research is needed to clarify the dosage of some vaccines.

ANNALS OF GERIATRIC MEDICINE AND RESEARCH (2021)

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Article Biotechnology & Applied Microbiology

Knowledge and practice of vaccination logistics management among primary health care workers in Nigeria

Wasiu Olalekan Adebimpe et al.

Summary: The study assessed the knowledge and practice of vaccination logistic management systems among primary health care workers in Osun state, Nigeria. It found that there are gaps in the knowledge, attitude, and practice of vaccination cold chain logistic system among the studied respondents, which should be addressed by stakeholders in immunization programs.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2021)

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Article Multidisciplinary Sciences

Prevention of tuberculosis in macaques after intravenous BCG immunization

Patricia A. Darrah et al.

NATURE (2020)

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Article Chemistry, Multidisciplinary

Design and Optimization of a Temperature-Stable Dry Powder BCG Vaccine

Dominique N. Price et al.

PHARMACEUTICAL RESEARCH (2020)

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Letter Allergy

Is global BCG vaccination-induced trained immunity relevant to the progression of SARS-CoV-2 pandemic?

Mayda Gursel et al.

ALLERGY (2020)

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Review Biochemistry & Molecular Biology

Trained Immunity: a Tool for Reducing Susceptibility to and the Severity of SARS-CoV-2 Infection

Mihai G. Netea et al.

CELL (2020)

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Letter Medicine, General & Internal

SARS-CoV-2 Rates in BCG-Vaccinated and Unvaccinated Young Adults

Uri Hamiel et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

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Article Gastroenterology & Hepatology

Safety and Optimal Timing of BCG Vaccination in Infants Born to Mothers Receiving Anti-TNF Therapy for Inflammatory Bowel Disease

Sang Hyoung Park et al.

JOURNAL OF CROHNS & COLITIS (2020)

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Review Immunology

Treatment options for COVID-19: The reality and challenges

Shio-Shin Jean et al.

JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION (2020)

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Article Medicine, General & Internal

India under COVID-19 lockdown

The Lancet

LANCET (2020)

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Article Immunology

Could BCG Vaccination Induce Protective Trained Immunity for SARS-CoV-2?

Camila Covian et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Editorial Material Biotechnology & Applied Microbiology

The COVID-19 vaccine development landscape

Tung Thanh Le et al.

NATURE REVIEWS DRUG DISCOVERY (2020)

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Article Immunology

Single-administration, thermostable human papillomavirus vaccines prepared with atomic layer deposition technology

Robert L. Garcea et al.

NPJ VACCINES (2020)

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Article Microbiology

BCG Vaccination in Humans Elicits Trained Immunity via the Hematopoietic Progenitor Compartment

Branko Cirovic et al.

CELL HOST & MICROBE (2020)

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Editorial Material Public, Environmental & Occupational Health

COVID-19: Could India still escape?

Ashwin Rammohan et al.

JOURNAL OF GLOBAL HEALTH (2020)

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Review Medicine, General & Internal

Advances in the use of chloroquine and hydroxychloroquine for the treatment of COVID-19

JingKang Sun et al.

POSTGRADUATE MEDICINE (2020)

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Article Multidisciplinary Sciences

BCG vaccine protection from severe coronavirus disease 2019 (COVID-19)

Luis E. Escobar et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

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Article Medicine, General & Internal

Safety and Immunogenicity of SARS-CoV-2 mRNA-1273 Vaccine in Older Adults

E. J. Anderson et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Article

Is the tuberculosis vaccine BCG an alternative weapon for developing countries to defeat COVID-19?

Wenping Gong et al.

Indian Journal of Tuberculosis (2020)

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Review Immunology

The SARS-CoV-2 Spike Glycoprotein Biosynthesis, Structure, Function, and Antigenicity: Implications for the Design of Spike-Based Vaccine Immunogens

Liangwei Duan et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Medicine, General & Internal

On the relationship between BCG coverage and national COVID-19 outcome: could 'heterologous' herd immunity explain why some countries are better off?

M. Lerm

JOURNAL OF INTERNAL MEDICINE (2020)

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Article Multidisciplinary Sciences

An ecological study to evaluate the association of Bacillus Calmette-Guerin (BCG) vaccination on cases of SARS-CoV2 infection and mortality from COVID-19

Lucy Chimoyi et al.

PLOS ONE (2020)

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Article Microbiology

Analysis of Measles-Mumps-Rubella (MMR) Titers of Recovered COVID-19 Patients

Jeffrey E. Gold et al.

MBIO (2020)

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Article Multidisciplinary Sciences

SARS-CoV-2 spike-protein D614G mutation increases virion spike density and infectivity

Lizhou Zhang et al.

NATURE COMMUNICATIONS (2020)

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Review Medicine, General & Internal

A review of the safety of vaccines used in routine immunization in Africa

Peter Yamoah et al.

AFRICAN HEALTH SCIENCES (2020)

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Review Immunology

Defining trained immunity and its role in health and disease

Mihai G. Netea et al.

NATURE REVIEWS IMMUNOLOGY (2020)

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Review Immunology

Trained immunity as a novel approach against COVID-19 with a focus on Bacillus Calmette-Guerin vaccine: mechanisms, challenges and perspectives

Yahya Sohrabi et al.

CLINICAL & TRANSLATIONAL IMMUNOLOGY (2020)

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Review Immunology

Emerging Principles in Myelopoiesis at Homeostasis and during Infection and Inflammation

Joachim L. Schultze et al.

IMMUNITY (2019)

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Article Multidisciplinary Sciences

Outcomes of controlled human malaria infection after BCG vaccination

Jona Walk et al.

NATURE COMMUNICATIONS (2019)

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Article Immunology

RUTI Vaccination Enhances Inhibition of Mycobacterial Growth ex vivo and Induces a Shift of Monocyte Phenotype in Mice

Satria A. Prabowo et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Article Immunology

Antibodies and vaccines against Middle East respiratory syndrome coronavirus

Jiuyang Xu et al.

EMERGING MICROBES & INFECTIONS (2019)

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Editorial Material Biochemistry & Molecular Biology

Immune Training Unlocks Innate Potential

Wilbur M. Song et al.

CELL (2018)

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Article Biochemistry & Molecular Biology

Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity

Ioannis Mitroulis et al.

CELL (2018)

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Article Biochemistry & Molecular Biology

BCG Educates Hematopoietic Stem Cells to Generate Protective Innate Immunity against Tuberculosis

Eva Kaufmann et al.

CELL (2018)

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Article Microbiology

BCG Vaccination Protects against Experimental Viral Infection in Humans through the Induction of Cytokines Associated with Trained Immunity

Rob J. W. Arts et al.

CELL HOST & MICROBE (2018)

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Review Biotechnology & Applied Microbiology

The current status, challenges, and future developments of new tuberculosis vaccines

Wenping Gong et al.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2018)

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Review Biochemistry & Molecular Biology

Carbonic Anhydrase Inhibitors as Novel Drugs against Mycobacterial beta-Carbonic Anhydrases: An Update on In Vitro and In Vivo Studies

Ashok Aspatwar et al.

MOLECULES (2018)

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Review Microbiology

Viral-Induced Enhanced Disease Illness

Maria K. Smatti et al.

FRONTIERS IN MICROBIOLOGY (2018)

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Article Immunology

Safety and Immunogenicity of the Recombinant Mycobacterium bovis BCG Vaccine VPM1002 in HIV-Unexposed Newborn Infants in South Africa

Andre G. Loxton et al.

CLINICAL AND VACCINE IMMUNOLOGY (2017)

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Review Immunology

The Recombinant Bacille Calmette-Guerin Vaccine VPM1002: Ready for Clinical Efficacy Testing

Natalie E. Nieuwenhuizen et al.

FRONTIERS IN IMMUNOLOGY (2017)

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Editorial Material Microbiology

Sleeping Beauty and the Story of the Bacille Calmette-Guerin Vaccine

Helen A. Fletcher

MBIO (2016)

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Article Cell Biology

Immunometabolic Pathways in BCG-Induced Trained Immunity

Rob J. W. Arts et al.

CELL REPORTS (2016)

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Article Infectious Diseases

Immunogenicity of BCG in HIV-exposed and non-exposed infants following routine birth or delayed vaccination

A. C. Hesseling et al.

INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE (2015)

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Article Multidisciplinary Sciences

Safety, Tolerability, and Immunogenicity of the Novel Antituberculous Vaccine RUTI: Randomized, Placebo-Controlled Phase II Clinical Trial in Patients with Latent Tuberculosis Infection

Andre S. Nell et al.

PLOS ONE (2014)

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Article Multidisciplinary Sciences

mTOR- and HIF-1α-mediated aerobic glycolysis as metabolic basis for trained immunity

Shih-Chin Cheng et al.

SCIENCE (2014)

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Article Biochemistry & Molecular Biology

Latent Enhancers Activated by Stimulation in Differentiated Cells

Renato Ostuni et al.

CELL (2013)

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Article Dermatology

Treatment of Common and Plane Warts in Children with Topical Viable Bacillus Calmette-Guerin

Ahmed Salem et al.

PEDIATRIC DERMATOLOGY (2013)

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Article Immunology

Safety and immunogenicity of the recombinant BCG vaccine VPM1002 in a phase 1 open-label randomized clinical trial

Leander Grode et al.

VACCINE (2013)

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Article Immunology

Nonclinical Development of BCG Replacement Vaccine Candidates

Kamalakannan Velmurugan et al.

VACCINES (2013)

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Article Multidisciplinary Sciences

Bacille Calmette-Guerin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes

Johanneke Kleinnijenhuis et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

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Article Microbiology

Trained Immunity: A Memory for Innate Host Defense

Mihai G. Netea et al.

CELL HOST & MICROBE (2011)

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Letter Respiratory System

New therapeutic approach for latent tuberculosis infection

Sandeep Kumar Gupta

LUNG INDIA (2011)

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Article Immunology

Double-blind, randomized, placebo-controlled Phase I Clinical Trial of the therapeutical antituberculous vaccine RUTI®

C. Vilaplana et al.

VACCINE (2010)

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Article Immunology

Global safety of vaccines: strengthening systems for monitoring, management and the role of GACVS

Brigitte Autran et al.

EXPERT REVIEW OF VACCINES (2009)

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Review Microbiology

Coronaviruses post-SARS: update on replication and pathogenesis

Stanley Perlman et al.

NATURE REVIEWS MICROBIOLOGY (2009)

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Article Immunology

RUTI: A new chance to shorten the treatment of latent tuberculosis infection

Pere-Joan Cardona

TUBERCULOSIS (2006)

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