期刊
FERTILITY AND STERILITY
卷 106, 期 4, 页码 871-879出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.fertnstert.2016.07.1100
关键词
Endocrine disruptors; miRNAs; PGCs; transgenerational; reproduction
资金
- MINECO, Spain [BFU2013-42164-R]
Endocrine-disrupting chemicals (EDCs) are environmental pollutants that may change the homeostasis of the endocrine system, altering the differentiation of germ cells with consequences for reproduction. In mammals, germ cell differentiation begins with primordial germ cells (PGCs) during embryogenesis. Primordial germ cell development and gametogenesis are genetically regulated processes, in which the posttranscriptional gene regulation could be mediated by small noncoding RNAs (sncRNAs) such as microRNAs (miRNAs). Here, we review the deleterious effects of exposure during fetal life to EDCs mediated by deregulation of ncRNAs, and specifically miRNAs on PGC differentiation. Moreover, the environmental stress induced by exposure to some EDCs during the embryonic window of development could trigger reproductive dysfunctions transgenerationally transmitted by epigenetic mechanisms with the involvement of miRNAs expressed in germ line cells. (C) 2016 by American Society for Reproductive Medicine.
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