期刊
EXPERIMENTAL NEUROLOGY
卷 341, 期 -, 页码 -出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.expneurol.2021.113721
关键词
Neuroinflammation; TBI; IBA-1; GFAP; Weight drop; IntelliCage; Memory and learning; Handedness
资金
- German Federal Ministry of Education and Research [BMBF 01EW1502B]
- Interdisciplinary Clinical Research Center (IZKF) Wurzburg [E313, Z3/69]
Traumatic brain injury (TBI) is often associated with sustained attention and memory deficits. Persisting neuroinflammation and neurodegeneration post-TBI may contribute to psychomotor dysfunction. The study found deficits in learning and memory in male mice three months after injury, correlating with severity of initial trauma. Analysis of brain cellular reactions showed persistent microgliosis and astrogliosis in defined regions, indicating a role of inflammatory reactions in posttraumatic memory deficits.
Traumatic brain injury (TBI) is often associated with sustained attention and memory deficits. As persisting neuroinflammation and neurodegeneration may contribute to posttraumatic psychomotor dysfunction, we studied the relationship of brain cellular reactions three months after a weight-drop closed head injury in male mice with posttraumatic learning and memory using automated home-cage monitoring of socially housed mice in IntelliCages as well as tests for locomotor activity, anxiety and forepaw fine motor skills. One month after TBI, deficits in place learning and cognitive flexibility in reverse learning were clearly detectable in IntelliCages and these memory deficits correlated with the initial trauma severity on the functional neuroscore. While sucrose preference or its extinction were not influenced by TBI, traumatized mice performed significantly worse in a complex episodic memory learning task. In consecutive locomotor and forepaw skilled use tests, posttraumatic hyperactivity and impairment of contralateral paw use were evident. Analysis of cellular reactions to TBI three months after injury in selected defined regions of interest in the immediate lesion, ipsi- and contralateral frontoparietal cortex and hippocampus revealed a persistent microgliosis and astrogliosis which were accompanied by iron-containing macrophages and myelin degradation in the lesion area as well as with axonal damage in the neighboring cortical regions. Microglial and astroglial reactions in cortex showed a positive correlation with the initial trauma severity and a negative correlation with the spatial and episodic memory indicating a role of brain inflammatory reactions in posttraumatic memory deficits.
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