期刊
EXPERIMENTAL NEUROLOGY
卷 342, 期 -, 页码 -出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.expneurol.2021.113744
关键词
Chronic unpredictable stress; Paraventricular thalamus (PVT); Central amygdala (CeA); Neuronal projection; Depression
资金
- Projects of Medical and Health Technology Development Program in Shandong Province, China [202003090720, 202003070728]
- Shandong Provincial Natural Science Foundation [ZR2014HQ080, ZR2018PH016, ZR2020MH060]
- National Natural Science Foundation of China [81601189]
- Scientific Research Foundation of Binzhou Medical University [BY2019KJ02, BY2016KYQD23]
This study reveals that PVT plays a key role in MDD, and the PVT-CeA projection regulates depression-related behaviors in a sex-dependent manner.
The dysregulation of neuronal networks may contribute to the etiology of major depressive disorder (MDD). However, the neural connections underlying the symptoms of MDD have yet to be elucidated. Here, we observed that glutamatergic neurons in the paraventricular thalamus (PVT) were activated by chronic unpredictable stress (CUS) with higher expression numbers of Delta FosB-labeled neurons and protein expression levels, activation of PVT neurons caused depressive-like phenotypes, whereas suppression of PVT neuronal activity induced an antidepressant effect in male, but not female mice, which were achieved by using a chemogenetic approach. Moreover, we found that PVT glutamatergic neurons showed strong neuronal projections to the central amygdala (CeA), activation of the CeA-projecting neurons in PVT or the neuronal terminals of PVT-CeA projection neurons induced depression-related behaviors or showed enhanced stress-induced susceptibility. These results suggest that PVT is a key depression-controlling nucleus, and PVT-CeA projection regulates depression-related behaviors in a sex-dependent manner, which could be served as an essential pathway for morbidity and treatment of depression.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据