Shutting the gate: targeting endocytosis in acute leukemia

Endocytosis entails selective packaging of cell surface cargos in cytoplasmic vesicles, thereby controlling key intrinsic cellular processes as well as the response of normal and malignant cells to their microenvironment. The purpose of this review is to outline the latest advances in the development of endocytosis-targeting therapeutic strategies in hematological malignancies. (c) 2021 ISEH - Society for Hematology and Stem Cells. Published by Elsevier Inc. All rights reserved.

Automated summary

Endocytosis plays a crucial role in controlling cellular processes and cellular responses to the microenvironment. Targeting therapeutic strategies based on endocytosis show promise for the treatment of hematological malignancies.