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Shenghui He et al.
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Timothy Nacarelli et al.
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Aika Nojima et al.
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J. Julie Wu et al.
CELL REPORTS (2013)
Chronic akt activation accentuates aging-induced cardiac hypertrophy and myocardial contractile dysfunction: role of autophagy
Yinan Hua et al.
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Asad M. Taherbhoy et al.
MOLECULAR CELL (2011)
Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Inhibitors: Rationale and Importance to Inhibiting These Pathways in Human Health
William H. Chappell et al.
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mTOR regulation of autophagy
Chang Hwa Jung et al.
FEBS LETTERS (2010)
Activation of the PI3K-Akt-mTOR signaling pathway promotes necrotic cell death via suppression of autophagy
You-Tong Wu et al.
AUTOPHAGY (2009)
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David E. Harrison et al.
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H Miyauchi et al.
EMBO JOURNAL (2004)
Replicative senescence: a critical review
VJ Cristofalo et al.
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