期刊
EXPERIMENTAL GERONTOLOGY
卷 155, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.exger.2021.111557
关键词
Frailty; Dementia; Blood pressure; Hypertension; Ageing
资金
- National Institute for Health Research (NIHR), (NIHR Development and Skills Enhancement Fellowship) [NIHR301445]
- National Institute for Health Research (NIHR)
- National Institutes of Health Research (NIHR) [NIHR301445] Funding Source: National Institutes of Health Research (NIHR)
High blood pressure affects 75% of people over 70, with aging causing changes in BP homeostasis, resulting in postural hypotension and increased BP variability. Understanding BP changes in later life is complex due to comorbidity and frailty, and longitudinal declines in BP are likely driven by accumulating comorbidity, accelerated in both frailty and dementia. This review summarises the association between BP and frailty, clinical management of BP in frailty, and the association between BP, cognitive decline, and dementia.
High blood pressure (BP) affects 75% of people aged over 70. Ageing alters BP homeostasis, resulting in postural hypotension and increased BP variability. Co-morbidity and frailty add complexity to understanding BP changes in later life. Longitudinal BP declines are likely driven by accumulating co-morbidity and are accelerated in both frailty and dementia. This narrative review summarises what is known about the association between BP and frailty, the clinical management of BP in frailty and the association between BP, cognitive decline and dementia.
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