期刊
EVOLUTIONARY APPLICATIONS
卷 14, 期 9, 页码 2162-2178出版社
WILEY
DOI: 10.1111/eva.13285
关键词
agriculture; gene drive; genetic control; pest control; resistance; risk analysis; underdominance
资金
- CSIRO Synthetic Biology Future Science Platform
Recent advances in gene-editing technologies have created new opportunities for genetic pest control strategies using gene drives. However, uncertainties remain regarding the applicability of these strategies to novel target species, their effectiveness in natural populations, and their safety as control methods.
Recent advances in gene-editing technologies have opened new avenues for genetic pest control strategies, in particular around the use of gene drives to suppress or modify pest populations. Significant uncertainty, however, surrounds the applicability of these strategies to novel target species, their efficacy in natural populations and their eventual safety and acceptability as control methods. In this article, we identify issues associated with the potential use of gene drives in agricultural systems, to control pests and diseases that impose a significant cost to agriculture around the world. We first review the need for innovative approaches and provide an overview of the most relevant biological and ecological traits of agricultural pests that could impact the outcome of gene drive approaches. We then describe the specific challenges associated with using gene drives in agricultural systems, as well as the opportunities that these environments may offer, focusing in particular on the advantages of high-threshold gene drives. Overall, we aim to provide a comprehensive view of the potential opportunities and the remaining uncertainties around the use of gene drives in agricultural systems.
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