On the need for integrating cancer into the One Health perspective

Recent pandemics have highlighted the urgency to connect disciplines studying animal, human, and environment health, that is, the One Health concept. The One Health approach takes a holistic view of health, but it has largely focused on zoonotic diseases while not addressing oncogenic processes. We argue that cancers should be an additional key focus in the One Health approach based on three factors that add to the well-documented impact of humans on the natural environment and its implications on cancer emergence. First, human activities are oncogenic to other animals, exacerbating the dynamics of oncogenesis, causing immunosuppressive disorders in wildlife with effects on host-pathogen interactions, and eventually facilitating pathogen spillovers. Second, the emergence of transmissible cancers in animal species (including humans) has the potential to accelerate biodiversity loss across ecosystems and to become pandemic. It is crucial to understand why, how, and when transmissible cancers emerge and spread. Third, translating knowledge of tumor suppressor mechanisms found across the Animal Kingdom to human health offers novel insights into cancer prevention and treatment strategies.

Automated summary

Recent pandemics have underscored the need to interconnect animal, human, and environmental health disciplines, under the concept of One Health. While the One Health approach primarily focuses on zoonotic diseases, the argument is made for cancers to also be a key concern due to human activities impacting the natural world and potentially leading to cancer emergence. Understanding transmissible cancers in animals, including humans, is crucial to prevent biodiversity loss and potential pandemics, while also offering new insights into cancer prevention and treatment strategies through research on tumor suppressor mechanisms.