Comment on: Transcriptomic analysis of CFTR-impaired endothelial cells reveals a pro-inflammatory phenotype

CFTR loss of function induces endothelial cell (EC) dysfunction. CFTR expression is reduced in pulmonary arterial ECs (PAECs) from patients with pulmonary arterial hypertension (PAH). Does CFTR loss of expression in PAECs contribute to PAH pathogenesis? https://bit.ly/3icWfa3

Automated summary

Loss of CFTR function leads to endothelial cell dysfunction, and reduced CFTR expression in pulmonary arterial endothelial cells from patients with pulmonary arterial hypertension might contribute to the pathogenesis of PAH.