期刊
EUROPEAN RADIOLOGY
卷 32, 期 1, 页码 300-307出版社
SPRINGER
DOI: 10.1007/s00330-021-08137-9
关键词
Language; Functional laterality; Brain neoplasms; Cerebellum; Magnetic resonance imaging
资金
- Agencia Nacional de Investigacion y Desarrollo (ANID Chile) grant FONDECYT [111150429]
- 2020 ANID doctoral scholarship [21201983]
The study demonstrated that semantic and phonological association tasks resulted in crossed cerebro-cerebellar language lateralization activations similar to those observed in the covert verb generation task. This suggests the possibility of using these tasks in conjunction with the traditional verb generation task, especially for subjects who may be unable to perform the latter.
Objectives Crossed cerebro-cerebellar BOLD activations have recently come to light as additional diagnostic features for patients with brain tumors. The covert verb generation (VG) task is a widely used language paradigm to determine these language-related crossed activations. Here we demonstrate these crossed activations in two additional language paradigms, the semantic and phonological association tasks. We propose the merit of these tasks to language lateralization determination in the clinic as they are easy to monitor and suitable for patients with aphasia. Methods Patients with brain tumors localized at different cortical sites (n = 71) performed three language paradigms, namely the VG task as well as the semantic (SA) and phonological (PA) association tasks with button-press responses. Respective language activations in disparate cortical regions and the cerebellum were assigned laterality. Agreements in laterality between the two new tasks and the verb generation task were tested using Cohen's kappa. Results Both tasks significantly agreed in cortical and cerebellar lateralization with the verb generation task in patients. Additionally, a McNemar test confirmed the presence of crossed activations in the cortex and the cerebellum in the entire subject population. Conclusion We demonstrated that the semantic and phonological association tasks resulted in crossed cerebro-cerebellar language lateralization activations as those observed due to the covert verb generation task. This may suggest the possibility of these tasks being used conjointly with the traditional verb generation task, especially for subjects that may be unable to perform the latter.
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